Abstract
One of the most actively developing fields in modern medicine is controlled drug delivery, an ability to keep optimal concentration of a drug at the desired body location. In particular, the most attention for potential use as drug delivery vehicles is drawn towards biodegradable polymeric materials. This is due to the versatility of tools for their fabrication, as well as due to the need to extract them after implantation being eliminated. In order to enhance polymer characteristics in terms of biocompatibility their surface can be functionalized. Plasma treatment is a method for the modification of material surface properties, which spans a wide range of applications in tissue engineering and regenerative medicine. The main advantage of this method is its ability to modify a polymeric surface without altering the bulk properties of materials, thus preserving original mechanical characteristics. Moreover, plasma modification is well-known for its speed, excluded need for solvents, and scalability. Recently, this approach has been gaining popularity for drug delivery applications. The applications of plasma treatment during the fabrication of drug delivery vehicles include surface activation, enhanced wettability, the fabrication of hydrophobic barrier layer, induced cross-linking and improved drug loading. This review covers the variety of approaches, applied to different polymeric biomaterials, including non-woven meshes, films, microparticles, microneedles and tablets, in order to achieve a controlled drug release. The applications of drug delivery devices with an implemented plasma treatment modification are also described.
| Original language | English |
|---|---|
| Pages (from-to) | 57-74 |
| Number of pages | 18 |
| Journal | Journal of Controlled Release |
| Volume | 266 |
| DOIs | |
| Publication status | Published - 28 Nov 2017 |
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Keywords
- Biodegradable polymers
- Controlled drug release
- Cross-linking
- Plasma treatment
- Surface modification
- Thin film deposition
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Plasma treatment as an efficient tool for controlled drug release from polymeric materials : A review. / Petlin, D. G.; Tverdokhlebov, S. I.; Anissimov, Y. G.
In: Journal of Controlled Release, Vol. 266, 28.11.2017, p. 57-74.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Plasma treatment as an efficient tool for controlled drug release from polymeric materials
T2 - A review
AU - Petlin, D. G.
AU - Tverdokhlebov, S. I.
AU - Anissimov, Y. G.
PY - 2017/11/28
Y1 - 2017/11/28
N2 - One of the most actively developing fields in modern medicine is controlled drug delivery, an ability to keep optimal concentration of a drug at the desired body location. In particular, the most attention for potential use as drug delivery vehicles is drawn towards biodegradable polymeric materials. This is due to the versatility of tools for their fabrication, as well as due to the need to extract them after implantation being eliminated. In order to enhance polymer characteristics in terms of biocompatibility their surface can be functionalized. Plasma treatment is a method for the modification of material surface properties, which spans a wide range of applications in tissue engineering and regenerative medicine. The main advantage of this method is its ability to modify a polymeric surface without altering the bulk properties of materials, thus preserving original mechanical characteristics. Moreover, plasma modification is well-known for its speed, excluded need for solvents, and scalability. Recently, this approach has been gaining popularity for drug delivery applications. The applications of plasma treatment during the fabrication of drug delivery vehicles include surface activation, enhanced wettability, the fabrication of hydrophobic barrier layer, induced cross-linking and improved drug loading. This review covers the variety of approaches, applied to different polymeric biomaterials, including non-woven meshes, films, microparticles, microneedles and tablets, in order to achieve a controlled drug release. The applications of drug delivery devices with an implemented plasma treatment modification are also described.
AB - One of the most actively developing fields in modern medicine is controlled drug delivery, an ability to keep optimal concentration of a drug at the desired body location. In particular, the most attention for potential use as drug delivery vehicles is drawn towards biodegradable polymeric materials. This is due to the versatility of tools for their fabrication, as well as due to the need to extract them after implantation being eliminated. In order to enhance polymer characteristics in terms of biocompatibility their surface can be functionalized. Plasma treatment is a method for the modification of material surface properties, which spans a wide range of applications in tissue engineering and regenerative medicine. The main advantage of this method is its ability to modify a polymeric surface without altering the bulk properties of materials, thus preserving original mechanical characteristics. Moreover, plasma modification is well-known for its speed, excluded need for solvents, and scalability. Recently, this approach has been gaining popularity for drug delivery applications. The applications of plasma treatment during the fabrication of drug delivery vehicles include surface activation, enhanced wettability, the fabrication of hydrophobic barrier layer, induced cross-linking and improved drug loading. This review covers the variety of approaches, applied to different polymeric biomaterials, including non-woven meshes, films, microparticles, microneedles and tablets, in order to achieve a controlled drug release. The applications of drug delivery devices with an implemented plasma treatment modification are also described.
KW - Biodegradable polymers
KW - Controlled drug release
KW - Cross-linking
KW - Plasma treatment
KW - Surface modification
KW - Thin film deposition
UR - http://www.scopus.com/inward/record.url?scp=85029695957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029695957&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2017.09.023
DO - 10.1016/j.jconrel.2017.09.023
M3 - Review article
AN - SCOPUS:85029695957
VL - 266
SP - 57
EP - 74
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
ER -