Abstract
Context: Endothelial dysfunction has been suggested as a potential mechanism by which ambient air pollution may cause acute cardiovascular events. Recently, plasma nitrite has been developed as a marker of endothelial dysfunction. Objectives: We examined the changes in plasma nitrite concentration associated with increases in ambient air pollutant concentrations in the previous 7 d. Materials and methods: We linked up to three measurements of plasma nitrite concentrations obtained from 49 students to 24-h average concentrations of five criteria air pollutants [particle mass3) and CO (161.7 parts per billion) concentrations in the first 24h before the plasma nitrite measurement were associated with increased plasma nitrite concentrations (PM2.5: 15.5 nanomolar; 95% confidence interval (CI): 2.4, 28.5; CO: 15.6 nanomolar; 95% CI: 2.4, 28.9). Increased plasma nitrite associated with IQR increases in O3 and SO2 concentrations over longer lags were observed. Discussion and conclusion: Rapid increases in plasma nitrite following exposure to ambient air pollutants support the hypothesis that ambient air pollution is associated with inducible nitric oxide synthase-mediated systemic inflammation in humans.
| Original language | English |
|---|---|
| Pages (from-to) | 426-434 |
| Number of pages | 9 |
| Journal | Inhalation Toxicology |
| Volume | 26 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
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Keywords
- Air pollution
- Ambient air pollutants
- Plasma nitrite concentration
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis
- Medicine(all)
Cite this
Plasma nitrite is an indicator of acute changes in ambient air pollutant concentrations. / Gandhi, Sampada K.; Rich, David Q.; Ohman-Strickland, Pamela A.; Kipen, Howard M.; Gow, Andrew.
In: Inhalation Toxicology, Vol. 26, No. 7, 2014, p. 426-434.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma nitrite is an indicator of acute changes in ambient air pollutant concentrations
AU - Gandhi, Sampada K.
AU - Rich, David Q.
AU - Ohman-Strickland, Pamela A.
AU - Kipen, Howard M.
AU - Gow, Andrew
PY - 2014
Y1 - 2014
N2 - Context: Endothelial dysfunction has been suggested as a potential mechanism by which ambient air pollution may cause acute cardiovascular events. Recently, plasma nitrite has been developed as a marker of endothelial dysfunction. Objectives: We examined the changes in plasma nitrite concentration associated with increases in ambient air pollutant concentrations in the previous 7 d. Materials and methods: We linked up to three measurements of plasma nitrite concentrations obtained from 49 students to 24-h average concentrations of five criteria air pollutants [particle mass3) and CO (161.7 parts per billion) concentrations in the first 24h before the plasma nitrite measurement were associated with increased plasma nitrite concentrations (PM2.5: 15.5 nanomolar; 95% confidence interval (CI): 2.4, 28.5; CO: 15.6 nanomolar; 95% CI: 2.4, 28.9). Increased plasma nitrite associated with IQR increases in O3 and SO2 concentrations over longer lags were observed. Discussion and conclusion: Rapid increases in plasma nitrite following exposure to ambient air pollutants support the hypothesis that ambient air pollution is associated with inducible nitric oxide synthase-mediated systemic inflammation in humans.
AB - Context: Endothelial dysfunction has been suggested as a potential mechanism by which ambient air pollution may cause acute cardiovascular events. Recently, plasma nitrite has been developed as a marker of endothelial dysfunction. Objectives: We examined the changes in plasma nitrite concentration associated with increases in ambient air pollutant concentrations in the previous 7 d. Materials and methods: We linked up to three measurements of plasma nitrite concentrations obtained from 49 students to 24-h average concentrations of five criteria air pollutants [particle mass3) and CO (161.7 parts per billion) concentrations in the first 24h before the plasma nitrite measurement were associated with increased plasma nitrite concentrations (PM2.5: 15.5 nanomolar; 95% confidence interval (CI): 2.4, 28.5; CO: 15.6 nanomolar; 95% CI: 2.4, 28.9). Increased plasma nitrite associated with IQR increases in O3 and SO2 concentrations over longer lags were observed. Discussion and conclusion: Rapid increases in plasma nitrite following exposure to ambient air pollutants support the hypothesis that ambient air pollution is associated with inducible nitric oxide synthase-mediated systemic inflammation in humans.
KW - Air pollution
KW - Ambient air pollutants
KW - Plasma nitrite concentration
UR - http://www.scopus.com/inward/record.url?scp=84901492204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901492204&partnerID=8YFLogxK
U2 - 10.3109/08958378.2014.913216
DO - 10.3109/08958378.2014.913216
M3 - Article
C2 - 24862977
AN - SCOPUS:84901492204
VL - 26
SP - 426
EP - 434
JO - Inhalation Toxicology
JF - Inhalation Toxicology
SN - 0895-8378
IS - 7
ER -