Plasma nitrite is an indicator of acute changes in ambient air pollutant concentrations

Sampada K. Gandhi, David Q. Rich, Pamela A. Ohman-Strickland, Howard M. Kipen, Andrew Gow

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Context: Endothelial dysfunction has been suggested as a potential mechanism by which ambient air pollution may cause acute cardiovascular events. Recently, plasma nitrite has been developed as a marker of endothelial dysfunction. Objectives: We examined the changes in plasma nitrite concentration associated with increases in ambient air pollutant concentrations in the previous 7 d. Materials and methods: We linked up to three measurements of plasma nitrite concentrations obtained from 49 students to 24-h average concentrations of five criteria air pollutants [particle mass3) and CO (161.7 parts per billion) concentrations in the first 24h before the plasma nitrite measurement were associated with increased plasma nitrite concentrations (PM2.5: 15.5 nanomolar; 95% confidence interval (CI): 2.4, 28.5; CO: 15.6 nanomolar; 95% CI: 2.4, 28.9). Increased plasma nitrite associated with IQR increases in O3 and SO2 concentrations over longer lags were observed. Discussion and conclusion: Rapid increases in plasma nitrite following exposure to ambient air pollutants support the hypothesis that ambient air pollution is associated with inducible nitric oxide synthase-mediated systemic inflammation in humans.

Original languageEnglish
Pages (from-to)426-434
Number of pages9
JournalInhalation Toxicology
Volume26
Issue number7
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Air pollution
  • Ambient air pollutants
  • Plasma nitrite concentration

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

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  • Cite this

    Gandhi, S. K., Rich, D. Q., Ohman-Strickland, P. A., Kipen, H. M., & Gow, A. (2014). Plasma nitrite is an indicator of acute changes in ambient air pollutant concentrations. Inhalation Toxicology, 26(7), 426-434. https://doi.org/10.3109/08958378.2014.913216