Plasma biomarkers of oxidative stress: Relationship to lung disease and inhaled nitric oxide therapy in premature infants

Philip L. Ballard, William E. Truog, Jeffrey D. Merrill, Andrew Gow, Michael Posencheg, Sergio G. Golombek, Lance A. Parton, Xianqun Luan, Avital Cnaan, Roberta A. Ballard

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objectives. Inhaled nitric oxide treatment for ventilated premature infants improves survival without bronchopulmonary dysplasia. However, there has been no information regarding possible effects of this therapy on oxidative stress. We hypothesized that inhaled nitric oxide therapy would not influence concentrations of plasma biomarkers of oxidative stress. Patients and Methods. As part of the Nitric Oxide Chronic Lung Disease Trial, we collected blood samples at specified intervals from a subpopulation of 100 infants of

Original languageEnglish
Pages (from-to)555-561
Number of pages7
JournalPediatrics
Volume121
Issue number3
DOIs
Publication statusPublished - Mar 2008
Externally publishedYes

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Keywords

  • 3-nitrotyrosine
  • Bronchopuimonary dysplasia
  • Carbonyl
  • Nitric oxide
  • Premature infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Ballard, P. L., Truog, W. E., Merrill, J. D., Gow, A., Posencheg, M., Golombek, S. G., Parton, L. A., Luan, X., Cnaan, A., & Ballard, R. A. (2008). Plasma biomarkers of oxidative stress: Relationship to lung disease and inhaled nitric oxide therapy in premature infants. Pediatrics, 121(3), 555-561. https://doi.org/10.1542/peds.2007-2479