Physicomechanical properties of the extracellular matrix of a demineralized bone

I. A. Kirilova, Yury Petrovich Sharkeev, S. V. Nikolaev, V. T. Podorozhnaya, P. V. Uvarkin, A. S. Ratushnyak, V. V. Chebodaeva

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Abstract

The article describes the results of a study of physicomechanical properties of a demineralized bone matrix of human cancellous and compact bones. A demineralized cancellous bone was shown to have the best characteristics of a porous system for colonization of matrices by cells. The ultimate stress and elasticity modulus of samples of demineralized femoral heads isolated in primary hip replacement was demonstrated to vary in wide ranges. The elasticity modulus ranged from 50 to 250 MPa, and the tensile strength varied from 1.1 to 5.5 MPa. Microhardness measurements by the recovered indentation method were not possible because of the viscoelastic properties of a bone material. To study the piezoelectric properties of samples, a measuring system was developed that comprised a measuring chamber with contact electrodes, a system for controlled sample loading, an amplifier-converter unit, and signal recording and processing software. The measurement results were used to determine the dependence of the signal amplitude on the dynamic deformation characteristics. The findings are discussed in terms of the relationship between the mechanical and electrical properties and the structure of the organic bone component.

Original languageEnglish
Article number020027
JournalAIP Conference Proceedings
Volume1760
DOIs
Publication statusPublished - 2 Aug 2016
EventInternational Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016, PC 2016 - Tomsk, Russian Federation
Duration: 22 Mar 201625 Mar 2016

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Kirilova, I. A., Sharkeev, Y. P., Nikolaev, S. V., Podorozhnaya, V. T., Uvarkin, P. V., Ratushnyak, A. S., & Chebodaeva, V. V. (2016). Physicomechanical properties of the extracellular matrix of a demineralized bone. AIP Conference Proceedings, 1760, [020027]. https://doi.org/10.1063/1.4960246