PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue

A. M. Demin, A. G. Pershina, K. V. Nevskaya, L. V. Efimova, N. N. Shchegoleva, M. A. Uimin, D. K. Kuznetsov, V. Ya Shur, V. P. Krasnov, L. M. Ogorodova

Research School of Chemistry & Applied Biomedical Sciences

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9 Citations (Scopus)

Abstract

Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe₃O₄ magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.

Original language	English
Pages (from-to)	60196-60199
Number of pages	4
Journal	RSC Advances
Volume	6
Issue number	65
DOIs	https://doi.org/10.1039/c6ra13178f
Publication status	Published - 2016

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ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

Cite this

Demin, A. M., Pershina, A. G., Nevskaya, K. V., Efimova, L. V., Shchegoleva, N. N., Uimin, M. A., ... Ogorodova, L. M. (2016). PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue. RSC Advances, 6(65), 60196-60199. https://doi.org/10.1039/c6ra13178f

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abstract = "Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.",

author = "Demin, {A. M.} and Pershina, {A. G.} and Nevskaya, {K. V.} and Efimova, {L. V.} and Shchegoleva, {N. N.} and Uimin, {M. A.} and Kuznetsov, {D. K.} and Shur, {V. Ya} and Krasnov, {V. P.} and Ogorodova, {L. M.}",

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language = "English",

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AU - Demin, A. M.

AU - Pershina, A. G.

AU - Nevskaya, K. V.

AU - Efimova, L. V.

AU - Shchegoleva, N. N.

AU - Uimin, M. A.

AU - Kuznetsov, D. K.

AU - Shur, V. Ya

AU - Krasnov, V. P.

AU - Ogorodova, L. M.

PY - 2016

Y1 - 2016

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10.1039/c6ra13178f