PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue

A. M. Demin, A. G. Pershina, K. V. Nevskaya, L. V. Efimova, N. N. Shchegoleva, M. A. Uimin, D. K. Kuznetsov, V. Ya Shur, V. P. Krasnov, L. M. Ogorodova

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.

Original languageEnglish
Pages (from-to)60196-60199
Number of pages4
JournalRSC Advances
Volume6
Issue number65
DOIs
Publication statusPublished - 2016

Fingerprint

Peptides
Nanoconjugates
Tissue
Nanoparticles
Magnetic resonance imaging
Tumors
pHLIP protein

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Demin, A. M., Pershina, A. G., Nevskaya, K. V., Efimova, L. V., Shchegoleva, N. N., Uimin, M. A., ... Ogorodova, L. M. (2016). PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue. RSC Advances, 6(65), 60196-60199. https://doi.org/10.1039/c6ra13178f

PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue. / Demin, A. M.; Pershina, A. G.; Nevskaya, K. V.; Efimova, L. V.; Shchegoleva, N. N.; Uimin, M. A.; Kuznetsov, D. K.; Shur, V. Ya; Krasnov, V. P.; Ogorodova, L. M.

In: RSC Advances, Vol. 6, No. 65, 2016, p. 60196-60199.

Research output: Contribution to journalArticle

Demin, AM, Pershina, AG, Nevskaya, KV, Efimova, LV, Shchegoleva, NN, Uimin, MA, Kuznetsov, DK, Shur, VY, Krasnov, VP & Ogorodova, LM 2016, 'PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue', RSC Advances, vol. 6, no. 65, pp. 60196-60199. https://doi.org/10.1039/c6ra13178f
Demin, A. M. ; Pershina, A. G. ; Nevskaya, K. V. ; Efimova, L. V. ; Shchegoleva, N. N. ; Uimin, M. A. ; Kuznetsov, D. K. ; Shur, V. Ya ; Krasnov, V. P. ; Ogorodova, L. M. / PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue. In: RSC Advances. 2016 ; Vol. 6, No. 65. pp. 60196-60199.
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AU - Uimin, M. A.

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