PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue

A. M. Demin, A. G. Pershina, K. V. Nevskaya, L. V. Efimova, N. N. Shchegoleva, M. A. Uimin, D. K. Kuznetsov, V. Ya Shur, V. P. Krasnov, L. M. Ogorodova

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9 Citations (Scopus)

Abstract

Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.

Original languageEnglish
Pages (from-to)60196-60199
Number of pages4
JournalRSC Advances
Volume6
Issue number65
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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  • Cite this

    Demin, A. M., Pershina, A. G., Nevskaya, K. V., Efimova, L. V., Shchegoleva, N. N., Uimin, M. A., Kuznetsov, D. K., Shur, V. Y., Krasnov, V. P., & Ogorodova, L. M. (2016). PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue. RSC Advances, 6(65), 60196-60199. https://doi.org/10.1039/c6ra13178f