PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue

A. M. Demin, A. G. Pershina, K. V. Nevskaya, L. V. Efimova, N. N. Shchegoleva, M. A. Uimin, D. K. Kuznetsov, V. Ya Shur, V. P. Krasnov, L. M. Ogorodova

Research School of Chemistry & Applied Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe₃O₄ magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.

Original language	English
Pages (from-to)	60196-60199
Number of pages	4
Journal	RSC Advances
Volume	6
Issue number	65
DOIs	https://doi.org/10.1039/c6ra13178f
Publication status	Published - 2016

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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10.1039/c6ra13178f

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title = "PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue",

abstract = "Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.",

author = "Demin, {A. M.} and Pershina, {A. G.} and Nevskaya, {K. V.} and Efimova, {L. V.} and Shchegoleva, {N. N.} and Uimin, {M. A.} and Kuznetsov, {D. K.} and Shur, {V. Ya} and Krasnov, {V. P.} and Ogorodova, {L. M.}",

year = "2016",

doi = "10.1039/c6ra13178f",

language = "English",

volume = "6",

pages = "60196--60199",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "65",

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TY - JOUR

T1 - PHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue

AU - Demin, A. M.

AU - Pershina, A. G.

AU - Nevskaya, K. V.

AU - Efimova, L. V.

AU - Shchegoleva, N. N.

AU - Uimin, M. A.

AU - Kuznetsov, D. K.

AU - Shur, V. Ya

AU - Krasnov, V. P.

AU - Ogorodova, L. M.

PY - 2016

Y1 - 2016

N2 - Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.

AB - Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.

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U2 - 10.1039/c6ra13178f

DO - 10.1039/c6ra13178f

M3 - Article

AN - SCOPUS:84976640760

VL - 6

SP - 60196

EP - 60199

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 65

ER -