Abstract
Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe3O4 magnetic nanoparticles was carried out resulting in the formation of MRI-visible materials able to specifically accumulate in acidic damaged tissue. The pH-dependent pHLIP-mediated binding of the obtained nanoconjugates to cells in acidic environment was demonstrated on HTC cells in vitro and in a mouse LLC tumour model in vivo.
Original language | English |
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Pages (from-to) | 60196-60199 |
Number of pages | 4 |
Journal | RSC Advances |
Volume | 6 |
Issue number | 65 |
DOIs | |
Publication status | Published - 2016 |
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)