Abstract
Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosil”, with high antiviral activity. Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry. Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues. Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 41-43 |
| Number of pages | 3 |
| Journal | International Journal of Pharmacy and Pharmaceutical Sciences |
| Volume | 7 |
| Issue number | 6 |
| Publication status | Published - 2015 |
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Keywords
- Antiviral drug
- Argosil
- Mass spectrometry
- Pharmacokinetics
- Silver distribution in tissues
- Silver-based complex
ASJC Scopus subject areas
- Pharmaceutical Science
- Pharmacology
Cite this
Pharmacokinetic studies of new silver-based complex. / Silnikov, Vladimir; Plotnikov, Evgenii; Plotnikov, Vladimir.
In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 7, No. 6, 2015, p. 41-43.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetic studies of new silver-based complex
AU - Silnikov, Vladimir
AU - Plotnikov, Evgenii
AU - Plotnikov, Vladimir
PY - 2015
Y1 - 2015
N2 - Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosil”, with high antiviral activity. Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry. Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues. Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment.
AB - Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosil”, with high antiviral activity. Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry. Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues. Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment.
KW - Antiviral drug
KW - Argosil
KW - Mass spectrometry
KW - Pharmacokinetics
KW - Silver distribution in tissues
KW - Silver-based complex
UR - http://www.scopus.com/inward/record.url?scp=84930661962&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930661962&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84930661962
VL - 7
SP - 41
EP - 43
JO - International Journal of Pharmacy and Pharmaceutical Sciences
JF - International Journal of Pharmacy and Pharmaceutical Sciences
SN - 0975-1491
IS - 6
ER -