Pharmacokinetic studies of new silver-based complex

Vladimir Silnikov, Evgenii Plotnikov, Vladimir Plotnikov

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C6H19Ag2N4LiO6S2, called “Argosil”, with high antiviral activity. Methods: Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry. Results: Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues. Conclusion: Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment.

Original languageEnglish
Pages (from-to)41-43
Number of pages3
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume7
Issue number6
Publication statusPublished - 2015

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Keywords

  • Antiviral drug
  • Argosil
  • Mass spectrometry
  • Pharmacokinetics
  • Silver distribution in tissues
  • Silver-based complex

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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