Perspective of creation of drugs on basis of opioids increasing cardiac tolerance to pathogenic impact of ischemia reperfusion

L. N. Maslov, Yu B. Lishmanov, J. P. Headrick, J. M. Pei, L. Hanuš, A. V. Krylatov, N. V. Naryzhnaya

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It was established that δ- and K1-opioid receptor (OR) stimulation both in vivo and in vitro promotes a decrease of infarct size/area at risk (IS/AAR) ratio during ischemia and reperfusion of heart. μ-OR activation increases a tolerance of isolated perfused heart to impact of ischemia and reperfusion but has no effect on IS/AAR index in vivo. The ORL1-receptor agonist nociceptin does not exert IS/AAR ratio in vivo. δ- and κ1-OR stimulation prevents cardiomyocyte apoptosis during ischemia and reperfiision of heart. The δ- and κ1-OR agonists mimic infarct-reducing effect of postconditioning. The OR inhibition does not impact IS/AAR index both in vivo and in vitro. The δ1- , δ2- and κ1-OR agonists are the most perspective group of opioids for creation of drugs increasing cardiac tolerance to pathogenic impact of ischemia and reperfusion.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume75
Issue number10
Publication statusPublished - 2012

Keywords

  • Heart
  • Ischemia
  • Opioid receptor ligands
  • Reperfusion

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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