Perfusion and metabolic scintigraphy with 123I-BMIPP in prognosis of cardiac resynchronization therapy in patients with dilated cardiomyopathy

Konstantin Valerievich Zavadovsky, Marina O. Gulya, Yuri B. Lishmanov, Denis I. Lebedev

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: The objective of the study was to investigate the left ventricular (LV) myocardial perfusion and metabolism in patients with idiopathic dilated cardiomyopathy (DCM) and to identify the scintigraphic predictors of the efficacy of cardiac resynchronization therapy (CRT). Methods: The study comprised 63 patients with DCM and severe heart failure (NYHA class III–IV). Before CRT, all patients received gamma-scintigraphy with 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) and with 123I-β-methyl-iodophenyl pentadecanoic acid (123I-BMIPP) for evaluation of myocardial perfusion and metabolism, respectively. Before and after 6 months of CRT, all patients underwent echocardiography study to assess cardiac hemodynamics. Results: After 6 months of CRT, patients were divided into two groups: group 1 comprised responders in whom LV end systolic volume (LVESV) decreased by ≥15 % (n = 39); group 2 comprised non-responders in whom LVESV decreased by

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalAnnals of Nuclear Medicine
DOIs
Publication statusAccepted/In press - 12 Feb 2016

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Cardiac Resynchronization Therapy
Perfusion Imaging
Dilated Cardiomyopathy
Perfusion
Radionuclide Imaging
Stroke Volume
Echocardiography
Heart Failure
Hemodynamics
iodofiltic acid

Keywords

  • Cardiac resynchronization therapy
  • Dilated cardiomyopathy
  • Myocardial scintigraphy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Perfusion and metabolic scintigraphy with 123I-BMIPP in prognosis of cardiac resynchronization therapy in patients with dilated cardiomyopathy. / Zavadovsky, Konstantin Valerievich; Gulya, Marina O.; Lishmanov, Yuri B.; Lebedev, Denis I.

In: Annals of Nuclear Medicine, 12.02.2016, p. 1-9.

Research output: Contribution to journalArticle

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