Peculiarities of cholinergic regulation of smooth muscles in rabbit pulmonary arteries

L. V. Kapilevich, Yana Jonovna Anfinogenova, M. B. Baskakov, I. V. Kovalec, A. V. Nosarev, M. A. Medvedev

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-induced relaxation was suppressed by denudation or nitric oxide synthase blocker L-NAME.

Original languageEnglish
Pages (from-to)728-730
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume130
Issue number8
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Pilocarpine
Cholinergic Agents
Pulmonary Artery
Endothelium
Smooth Muscle
Muscle
Rabbits
Muscarinic Agonists
NG-Nitroarginine Methyl Ester
Muscarinic Receptors
Nitric Oxide Synthase
Potassium

Keywords

  • Endothelium
  • Nitric oxide
  • Pulmonary arteries

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Peculiarities of cholinergic regulation of smooth muscles in rabbit pulmonary arteries. / Kapilevich, L. V.; Anfinogenova, Yana Jonovna; Baskakov, M. B.; Kovalec, I. V.; Nosarev, A. V.; Medvedev, M. A.

In: Bulletin of Experimental Biology and Medicine, Vol. 130, No. 8, 2000, p. 728-730.

Research output: Contribution to journalArticle

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