Peculiarities of cholinergic regulation of smooth muscles in rabbit pulmonary arteries

L. V. Kapilevich, Yana Jonovna Anfinogenova, M. B. Baskakov, I. V. Kovalec, A. V. Nosarev, M. A. Medvedev

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-induced relaxation was suppressed by denudation or nitric oxide synthase blocker L-NAME.

Original languageEnglish
Pages (from-to)728-730
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume130
Issue number8
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Endothelium
  • Nitric oxide
  • Pulmonary arteries

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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