Abstract
Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-induced relaxation was suppressed by denudation or nitric oxide synthase blocker L-NAME.
Original language | English |
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Pages (from-to) | 728-730 |
Number of pages | 3 |
Journal | Bulletin of Experimental Biology and Medicine |
Volume | 130 |
Issue number | 8 |
Publication status | Published - 2000 |
Externally published | Yes |
Keywords
- Endothelium
- Nitric oxide
- Pulmonary arteries
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)