Peculiarities of cholinergic regulation of smooth muscles in rabbit pulmonary arteries

L. V. Kapilevich, Yana Jonovna Anfinogenova, M. B. Baskakov, I. V. Kovalec, A. V. Nosarev, M. A. Medvedev

Research output: Contribution to journal › Article › peer-review

Abstract

Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-induced relaxation was suppressed by denudation or nitric oxide synthase blocker L-NAME.

Original language	English
Pages (from-to)	728-730
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	130
Issue number	8
Publication status	Published - 2000
Externally published	Yes

Keywords

Endothelium
Nitric oxide
Pulmonary arteries

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-induced relaxation was suppressed by denudation or nitric oxide synthase blocker L-NAME.",

keywords = "Endothelium, Nitric oxide, Pulmonary arteries",

author = "Kapilevich, {L. V.} and Anfinogenova, {Yana Jonovna} and Baskakov, {M. B.} and Kovalec, {I. V.} and Nosarev, {A. V.} and Medvedev, {M. A.}",

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AU - Kapilevich, L. V.

AU - Anfinogenova, Yana Jonovna

AU - Baskakov, M. B.

AU - Kovalec, I. V.

AU - Nosarev, A. V.

AU - Medvedev, M. A.

PY - 2000

Y1 - 2000

N2 - Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-induced relaxation was suppressed by denudation or nitric oxide synthase blocker L-NAME.

AB - Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-induced relaxation was suppressed by denudation or nitric oxide synthase blocker L-NAME.

KW - Endothelium

KW - Nitric oxide

KW - Pulmonary arteries

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