Peculiarities of Cell Seeding on Polylactic Acid-Based Scaffolds Fabricated Using Electrospinning and Solution Blow Spinning Technologies

S. A. Afanasiev, E. F. Muslimova, Yu A. Nashchekina, P. O. Nikonov, Yu V. Rogovskaya, E. N. Bolbasov, S. I. Tverdokhlebov

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We studied the possibility of seeding bone marrow-derived stromal cells onto polylactic acid-based scaffolds fabricated by electrospinning and solution blow spinning technologies. The cells were applied to the scaffolds by dynamic seeding and scaffolds were then cultured in Petri dishes in culture medium for 3 days. Cell migration to the Petri dish surface was noted only for scaffolds fabricated by electrospinning technology, but DAPI staining confirmed the presence of cells in both scaffolds. The mean number of cells in scaffolds fabricated by electrospinning and solution blow spinning was 56±9 and 81±6, respectively. The scaffold fabricated by solution blow spinning was more effectively (p<0.05) colonized by cells due to its more optimal spatial structure.

Original languageEnglish
Pages (from-to)281-284
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume164
Issue number2
DOIs
Publication statusPublished - 1 Dec 2017

Keywords

  • cell culture
  • electrospinning
  • polylactic acid
  • solution blow spinning
  • synthetic scaffold

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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