Peculiarities of adrenergic regulation of smooth muscles in rabbit pulmonary arteries

L. V. Kapilevich, A. V. Nosarev, E. Yu D'yakova, I. V. Kovalev, M. B. Baskakov, Yana Jonovna Anfinogenova, M. A. Medvedev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Muscle tension recording was used to study adrenergic contractile reactions of pulmonary artery smooth muscles in rabbits. Stimulation of α-adrenoceptors induced contraction of pulmonary artery smooth muscle cells. Endothelium partially inhibited the contractile effect of α-adrenoceptor agonists. Activation of smooth muscle β-adrenoceptors in pulmonary arteries produced a dual dose-dependent effect (relaxation at agonist concentrations of 10 nM-1 μM and contraction at concentrations above 10 μM). The contractile effect of β-adrenoceptor activation in smooth muscle cells is a specific feature of pulmonary arteries probably related to peculiarities of cAMP-signaling in these cells.

Original languageEnglish
Pages (from-to)214-216
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume133
Issue number3
DOIs
Publication statusPublished - Aug 2002
Externally publishedYes

Keywords

  • Adrenoceptors
  • cAMP
  • Endothelium
  • Pulmonary arteries
  • Smooth muscles

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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