Abstract
Muscle tension recording was used to study adrenergic contractile reactions of pulmonary artery smooth muscles in rabbits. Stimulation of α-adrenoceptors induced contraction of pulmonary artery smooth muscle cells. Endothelium partially inhibited the contractile effect of α-adrenoceptor agonists. Activation of smooth muscle β-adrenoceptors in pulmonary arteries produced a dual dose-dependent effect (relaxation at agonist concentrations of 10 nM-1 μM and contraction at concentrations above 10 μM). The contractile effect of β-adrenoceptor activation in smooth muscle cells is a specific feature of pulmonary arteries probably related to peculiarities of cAMP-signaling in these cells.
| Original language | English |
|---|---|
| Pages (from-to) | 214-216 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 133 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 2002 |
| Externally published | Yes |
Keywords
- Adrenoceptors
- cAMP
- Endothelium
- Pulmonary arteries
- Smooth muscles
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Kapilevich, L. V., Nosarev, A. V., D'yakova, E. Y., Kovalev, I. V., Baskakov, M. B., Anfinogenova, Y. J., & Medvedev, M. A. (2002). Peculiarities of adrenergic regulation of smooth muscles in rabbit pulmonary arteries. Bulletin of Experimental Biology and Medicine, 133(3), 214-216. https://doi.org/10.1023/A:1015862028565