Peculiarities of adrenergic regulation of smooth muscles in rabbit pulmonary arteries

Abstract

Muscle tension recording was used to study adrenergic contractile reactions of pulmonary artery smooth muscles in rabbits. Stimulation of α-adrenoceptors induced contraction of pulmonary artery smooth muscle cells. Endothelium partially inhibited the contractile effect of α-adrenoceptor agonists. Activation of smooth muscle β-adrenoceptors in pulmonary arteries produced a dual dose-dependent effect (relaxation at agonist concentrations of 10 nM-1 μM and contraction at concentrations above 10 μM). The contractile effect of β-adrenoceptor activation in smooth muscle cells is a specific feature of pulmonary arteries probably related to peculiarities of cAMP-signaling in these cells.

Original language	English
Pages (from-to)	214-216
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	133
Issue number	3
DOIs	https://doi.org/10.1023/A:1015862028565
Publication status	Published - Aug 2002
Externally published	Yes

Keywords

Adrenoceptors
cAMP
Endothelium
Pulmonary arteries
Smooth muscles

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1023/A:1015862028565

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Peculiarities of adrenergic regulation of smooth muscles in rabbit pulmonary arteries. / Kapilevich, L. V.; Nosarev, A. V.; D'yakova, E. Yu; Kovalev, I. V.; Baskakov, M. B.; Anfinogenova, Yana Jonovna; Medvedev, M. A.

In: Bulletin of Experimental Biology and Medicine, Vol. 133, No. 3, 08.2002, p. 214-216.

Research output: Contribution to journal › Article › peer-review

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AU - Nosarev, A. V.

AU - D'yakova, E. Yu

AU - Kovalev, I. V.

AU - Baskakov, M. B.

AU - Anfinogenova, Yana Jonovna

AU - Medvedev, M. A.

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