Abstract
Muscle tension recording was used to study adrenergic contractile reactions of pulmonary artery smooth muscles in rabbits. Stimulation of α-adrenoceptors induced contraction of pulmonary artery smooth muscle cells. Endothelium partially inhibited the contractile effect of α-adrenoceptor agonists. Activation of smooth muscle β-adrenoceptors in pulmonary arteries produced a dual dose-dependent effect (relaxation at agonist concentrations of 10 nM-1 μM and contraction at concentrations above 10 μM). The contractile effect of β-adrenoceptor activation in smooth muscle cells is a specific feature of pulmonary arteries probably related to peculiarities of cAMP-signaling in these cells.
| Original language | English |
|---|---|
| Pages (from-to) | 214-216 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 133 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 2002 |
| Externally published | Yes |
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Keywords
- Adrenoceptors
- cAMP
- Endothelium
- Pulmonary arteries
- Smooth muscles
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Peculiarities of adrenergic regulation of smooth muscles in rabbit pulmonary arteries. / Kapilevich, L. V.; Nosarev, A. V.; D'yakova, E. Yu; Kovalev, I. V.; Baskakov, M. B.; Anfinogenova, Yana Jonovna; Medvedev, M. A.
In: Bulletin of Experimental Biology and Medicine, Vol. 133, No. 3, 08.2002, p. 214-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peculiarities of adrenergic regulation of smooth muscles in rabbit pulmonary arteries
AU - Kapilevich, L. V.
AU - Nosarev, A. V.
AU - D'yakova, E. Yu
AU - Kovalev, I. V.
AU - Baskakov, M. B.
AU - Anfinogenova, Yana Jonovna
AU - Medvedev, M. A.
PY - 2002/8
Y1 - 2002/8
N2 - Muscle tension recording was used to study adrenergic contractile reactions of pulmonary artery smooth muscles in rabbits. Stimulation of α-adrenoceptors induced contraction of pulmonary artery smooth muscle cells. Endothelium partially inhibited the contractile effect of α-adrenoceptor agonists. Activation of smooth muscle β-adrenoceptors in pulmonary arteries produced a dual dose-dependent effect (relaxation at agonist concentrations of 10 nM-1 μM and contraction at concentrations above 10 μM). The contractile effect of β-adrenoceptor activation in smooth muscle cells is a specific feature of pulmonary arteries probably related to peculiarities of cAMP-signaling in these cells.
AB - Muscle tension recording was used to study adrenergic contractile reactions of pulmonary artery smooth muscles in rabbits. Stimulation of α-adrenoceptors induced contraction of pulmonary artery smooth muscle cells. Endothelium partially inhibited the contractile effect of α-adrenoceptor agonists. Activation of smooth muscle β-adrenoceptors in pulmonary arteries produced a dual dose-dependent effect (relaxation at agonist concentrations of 10 nM-1 μM and contraction at concentrations above 10 μM). The contractile effect of β-adrenoceptor activation in smooth muscle cells is a specific feature of pulmonary arteries probably related to peculiarities of cAMP-signaling in these cells.
KW - Adrenoceptors
KW - cAMP
KW - Endothelium
KW - Pulmonary arteries
KW - Smooth muscles
UR - http://www.scopus.com/inward/record.url?scp=0036695709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036695709&partnerID=8YFLogxK
U2 - 10.1023/A:1015862028565
DO - 10.1023/A:1015862028565
M3 - Article
VL - 133
SP - 214
EP - 216
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 3
ER -