Abstract
Specific post-translational modifications resulting from the reaction of nitric oxide or nitric oxide-derived reactive nitrogen species with selective proteins may explain the pleiotropic effects of this molecule in biological systems. Three specific reactions, binding to metal centers, nitrosation of nucleophilic centers and nitration of aromatic residues constitute a major component of the biological reactivity of nitric oxide. We postulate that the chemical reactivity of nitric oxide within biological systems allows this simple diatomic molecule to operate as an integrator of physiological homeostasis and potentially under not completely understood circumstances as a mediator of pathological phenotypes. This chapter reviews the chemistry, putative biological functions and significance of the principal nitric oxide-mediated proteins modifications.
| Original language | English |
|---|---|
| Pages (from-to) | 299-303 |
| Number of pages | 5 |
| Journal | Toxicology |
| Volume | 208 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 15 Mar 2005 |
| Externally published | Yes |
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Keywords
- Nitric oxide
- Pathophysiological functions
- Protein
ASJC Scopus subject areas
- Toxicology
Cite this
Pathophysiological functions of nitric oxide-mediated protein modifications. / Ischiropoulos, Harry; Gow, Andrew.
In: Toxicology, Vol. 208, No. 2, 15.03.2005, p. 299-303.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pathophysiological functions of nitric oxide-mediated protein modifications
AU - Ischiropoulos, Harry
AU - Gow, Andrew
PY - 2005/3/15
Y1 - 2005/3/15
N2 - Specific post-translational modifications resulting from the reaction of nitric oxide or nitric oxide-derived reactive nitrogen species with selective proteins may explain the pleiotropic effects of this molecule in biological systems. Three specific reactions, binding to metal centers, nitrosation of nucleophilic centers and nitration of aromatic residues constitute a major component of the biological reactivity of nitric oxide. We postulate that the chemical reactivity of nitric oxide within biological systems allows this simple diatomic molecule to operate as an integrator of physiological homeostasis and potentially under not completely understood circumstances as a mediator of pathological phenotypes. This chapter reviews the chemistry, putative biological functions and significance of the principal nitric oxide-mediated proteins modifications.
AB - Specific post-translational modifications resulting from the reaction of nitric oxide or nitric oxide-derived reactive nitrogen species with selective proteins may explain the pleiotropic effects of this molecule in biological systems. Three specific reactions, binding to metal centers, nitrosation of nucleophilic centers and nitration of aromatic residues constitute a major component of the biological reactivity of nitric oxide. We postulate that the chemical reactivity of nitric oxide within biological systems allows this simple diatomic molecule to operate as an integrator of physiological homeostasis and potentially under not completely understood circumstances as a mediator of pathological phenotypes. This chapter reviews the chemistry, putative biological functions and significance of the principal nitric oxide-mediated proteins modifications.
KW - Nitric oxide
KW - Pathophysiological functions
KW - Protein
UR - http://www.scopus.com/inward/record.url?scp=13244284790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13244284790&partnerID=8YFLogxK
U2 - 10.1016/j.tox.2004.11.018
DO - 10.1016/j.tox.2004.11.018
M3 - Review article
C2 - 15691593
AN - SCOPUS:13244284790
VL - 208
SP - 299
EP - 303
JO - Toxicology
JF - Toxicology
SN - 0300-483X
IS - 2
ER -