Abstract
Far-red and near-infrared fluorescent quantum dots (QDs) have become advancing contrast agents for efficient whole-body tumor imaging. In this study, we investigated the possibility of the vital fluorescence imaging of tumor using two contrast agents on the basis of QDs: bioinert QDs coated with polyethyleneglycol and QDs bound with anti-HER2/neu scFv antibodies. HER2/neu-positive breast cancer tumor xenografts in nude mice were used as a model. It was shown that both bioinert and tumor-targeted QD probes can be successfully applied for visualization of the tumor using in vivo imaging method, but fluorescent signal of QD-4D5scFv in tumors was considerably stronger than that of QD-PEG.
| Original language | English |
|---|---|
| Pages (from-to) | 860-867 |
| Number of pages | 8 |
| Journal | Journal of Biophotonics |
| Volume | 5 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - Nov 2012 |
| Externally published | Yes |
Keywords
- Breast cancer
- Fluorescence
- HER2/neu
- Quantum dots
- ScFv antibodies
- Whole-body imaging
ASJC Scopus subject areas
- Materials Science(all)
- Engineering(all)
- Physics and Astronomy(all)
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Balalaeva, I. V., Zdobnova, T. A., Krutova, I. V., Brilkina, A. A., Lebedenko, E. N., & Deyev, S. M. (2012). Passive and active targeting of quantum dots for whole-body fluorescence imaging of breast cancer xenografts. Journal of Biophotonics, 5(11-12), 860-867. https://doi.org/10.1002/jbio.201200080