Abstract
Far-red and near-infrared fluorescent quantum dots (QDs) have become advancing contrast agents for efficient whole-body tumor imaging. In this study, we investigated the possibility of the vital fluorescence imaging of tumor using two contrast agents on the basis of QDs: bioinert QDs coated with polyethyleneglycol and QDs bound with anti-HER2/neu scFv antibodies. HER2/neu-positive breast cancer tumor xenografts in nude mice were used as a model. It was shown that both bioinert and tumor-targeted QD probes can be successfully applied for visualization of the tumor using in vivo imaging method, but fluorescent signal of QD-4D5scFv in tumors was considerably stronger than that of QD-PEG.
Original language | English |
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Pages (from-to) | 860-867 |
Number of pages | 8 |
Journal | Journal of Biophotonics |
Volume | 5 |
Issue number | 11-12 |
DOIs | |
Publication status | Published - Nov 2012 |
Externally published | Yes |
Keywords
- Breast cancer
- Fluorescence
- HER2/neu
- Quantum dots
- ScFv antibodies
- Whole-body imaging
ASJC Scopus subject areas
- Materials Science(all)
- Engineering(all)
- Physics and Astronomy(all)
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)