Participation of central kappa-opioid receptor in arrhythmogenesis

Yu B. Lishmanov, L. N. Maslov, D. S. Ugdyzhekova, G. N. Smagin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effect of kappa receptors agonists and antagonists was studied in the model of epinephrine induced arrhythmias. Kappa receptor agonists U-50,488 and [D-Ala2]-Dynorphin A (1-13) administered ICV potentiate the arrhythmogenic effect of epinephrine. The effect of U-50,488 was completely blocked by kappa receptor antagonist, nor-binaltorphine. Administration of N-cholinergic receptor inhibitor, hexamethonium, prevented pro-arrhythmic effects of U-50,488 and [D-Ala2]-Dynorphin A (1-13). The data support the hypothesis that central kappa opioid receptors play an important role in the arrhythmogenesis.

Original languageEnglish
JournalLife Sciences
Volume61
Issue number3
DOIs
Publication statusPublished - 13 Jun 1997

Keywords

  • Dynorphin
  • Epinephrine arrhythmias
  • Hexamethonium
  • Nor-binaltorphine
  • U-50,488

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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