Participation of central and peripheral opioid receptors in mechanisms of arrhythmogenesis

Yu B. Lishmanov, L. N. Maslov

Research output: Contribution to journalArticle

Abstract

This study was designed to determine the role of opioid receptors (OR) in arrhythmogenesis in the models of epinephrine-, aconitine- and CaCl2-induced arrhythmias in rats. The OR ligands were injected icv at a dose of 20 nmol/rat or intravenously (iv) 30 min before the induction of arrhythmias. Mu-OR agonists (DAGO, DALDA) had antiarrhythmic effects with systemic and icv administration. Kappa-OR agonists (spiradoline, U-504488) exhibited antiarrhythmic properties only with iv administration, but icv infusion produced proarrhythmic effects. Ligands of central delta-ORs (DTLET, DSLET, DPDPE, DADLE) increased cardiac resistance to arrhythmogenic influences, but iv administration delta-OR agonists did not affect arrhythmias. The proarrhythmic effects of central administration of kappa-OR agonists were associated with the activation of sympathetic nervous system and were completely eliminated by hexomethonium (10 mg/kg, iv). Antiarrhythmic effects of mu-OR agonists injected icv were completely eliminated by atropine (iv and icv). The mechanisms of increased cardiac resistance to arrythmogenic agents after peripheral mu-OR activation appear to be unclear.

Original languageEnglish
JournalFASEB Journal
Volume11
Issue number3
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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