Abstract
This study was designed to determine the role of opioid receptors (OR) in arrhythmogenesis in the models of epinephrine-, aconitine- and CaCl2-induced arrhythmias in rats. The OR ligands were injected icv at a dose of 20 nmol/rat or intravenously (iv) 30 min before the induction of arrhythmias. Mu-OR agonists (DAGO, DALDA) had antiarrhythmic effects with systemic and icv administration. Kappa-OR agonists (spiradoline, U-504488) exhibited antiarrhythmic properties only with iv administration, but icv infusion produced proarrhythmic effects. Ligands of central delta-ORs (DTLET, DSLET, DPDPE, DADLE) increased cardiac resistance to arrhythmogenic influences, but iv administration delta-OR agonists did not affect arrhythmias. The proarrhythmic effects of central administration of kappa-OR agonists were associated with the activation of sympathetic nervous system and were completely eliminated by hexomethonium (10 mg/kg, iv). Antiarrhythmic effects of mu-OR agonists injected icv were completely eliminated by atropine (iv and icv). The mechanisms of increased cardiac resistance to arrythmogenic agents after peripheral mu-OR activation appear to be unclear.
| Original language | English |
|---|---|
| Journal | FASEB Journal |
| Volume | 11 |
| Issue number | 3 |
| Publication status | Published - 1997 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology
Cite this
Participation of central and peripheral opioid receptors in mechanisms of arrhythmogenesis. / Lishmanov, Yu B.; Maslov, L. N.
In: FASEB Journal, Vol. 11, No. 3, 1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Participation of central and peripheral opioid receptors in mechanisms of arrhythmogenesis
AU - Lishmanov, Yu B.
AU - Maslov, L. N.
PY - 1997
Y1 - 1997
N2 - This study was designed to determine the role of opioid receptors (OR) in arrhythmogenesis in the models of epinephrine-, aconitine- and CaCl2-induced arrhythmias in rats. The OR ligands were injected icv at a dose of 20 nmol/rat or intravenously (iv) 30 min before the induction of arrhythmias. Mu-OR agonists (DAGO, DALDA) had antiarrhythmic effects with systemic and icv administration. Kappa-OR agonists (spiradoline, U-504488) exhibited antiarrhythmic properties only with iv administration, but icv infusion produced proarrhythmic effects. Ligands of central delta-ORs (DTLET, DSLET, DPDPE, DADLE) increased cardiac resistance to arrhythmogenic influences, but iv administration delta-OR agonists did not affect arrhythmias. The proarrhythmic effects of central administration of kappa-OR agonists were associated with the activation of sympathetic nervous system and were completely eliminated by hexomethonium (10 mg/kg, iv). Antiarrhythmic effects of mu-OR agonists injected icv were completely eliminated by atropine (iv and icv). The mechanisms of increased cardiac resistance to arrythmogenic agents after peripheral mu-OR activation appear to be unclear.
AB - This study was designed to determine the role of opioid receptors (OR) in arrhythmogenesis in the models of epinephrine-, aconitine- and CaCl2-induced arrhythmias in rats. The OR ligands were injected icv at a dose of 20 nmol/rat or intravenously (iv) 30 min before the induction of arrhythmias. Mu-OR agonists (DAGO, DALDA) had antiarrhythmic effects with systemic and icv administration. Kappa-OR agonists (spiradoline, U-504488) exhibited antiarrhythmic properties only with iv administration, but icv infusion produced proarrhythmic effects. Ligands of central delta-ORs (DTLET, DSLET, DPDPE, DADLE) increased cardiac resistance to arrhythmogenic influences, but iv administration delta-OR agonists did not affect arrhythmias. The proarrhythmic effects of central administration of kappa-OR agonists were associated with the activation of sympathetic nervous system and were completely eliminated by hexomethonium (10 mg/kg, iv). Antiarrhythmic effects of mu-OR agonists injected icv were completely eliminated by atropine (iv and icv). The mechanisms of increased cardiac resistance to arrythmogenic agents after peripheral mu-OR activation appear to be unclear.
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M3 - Article
VL - 11
JO - FASEB Journal
JF - FASEB Journal
SN - 0892-6638
IS - 3
ER -