Participation of central and peripheral κ1 and κ2 opioid receptors in arrhythmogenesis

Yury B. Lishmanov, Leonid N. Maslov, Dina S. Ugdyzhekova

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

1. The κ1 and κ2 opioid receptor agonists U-62066 (8 mg/kg, i.p.) and (-)-bremazocine (0.7mg/kg, i.v.), respectively, both exhibit anti- arrhythmic properties against adrenaline-induced dysrhythmias in rats. 2. In contrast, (+)-bremazocine has no effect on adrenaline-induced dysrhythmias. 3. The κ1 opioid receptor agonists U-50 488 (110 nmol) and [D-Ala2]- dynorphin A (20 nmol) and the κ2 opioid receptor agonist (-)-bremazocine (30 nmol) exhibit pro-arrhythmic properties following intracerebroventricular administration. 4. Prior administration of the κ opioid receptor antagonist nor-binaltorphimine doses i.c.v. (14 nmol), i.p. (10 mg/kg), completely abolishes the pro-arrhythmic (BNI, i.c.v., 14 nmol) as well as anti- arrhythmic (BNI, 10 mg/kg, i.p.) effects of the κ opioid receptor agonists. 5. Neither hexamethonium (10 mg/kg, i.v.) nor atropine (1 mg/kg, i.v.) have any effect on the anti-arrhythmic actions of the κ1 opioid receptor agonist U-62066 following systemic administration. 6. It is suggested that the anti- arrhythmic effects of U-62066 and (-)-bremazocine are associated with the activation of peripheral κ opioid receptors and do not depend on the activation of κ opioid receptors in the autonomic nervous system.

Original languageEnglish
Pages (from-to)716-723
Number of pages8
JournalClinical and Experimental Pharmacology and Physiology
Volume26
Issue number9
DOIs
Publication statusPublished - 1999

Keywords

  • κ opioid receptors
  • κ opioid receptors
  • Dysrhythmias

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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