Oxygen Metabolism in the Lung

Andrew J. Gow, Henry J. Forman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Although most of the O2 delivered to the lung diffuses into the blood and is ultimately utilized by other tissues, the lung itself requires O2 for both energy metabolism and cellular signaling. The greatest use of O2 by lung cells, as typical cells, is in the generation of adenosine triphosphate (ATP). For this reason, we will focus a large part of this discussion on the mechanisms for generating ATP, rather than just on the more narrow area of cytochrome c oxidase activity. The lung is also the site of a number of other important biochemical roles for O2. These include the transformation of steroids and xenobiotics by cytochrome P450 and flavin monooxygenase; the production of nitric oxide; the oxidation of amines, such as serotonin; the formation of collagen and elastin cross-links by oxidative processes; the production of prostaglandins, leukotrienes, and related arachidonate metabolites; and the oxidative killing of microorganisms by phagocytes. Oxygen is used to generate hydrogen peroxide for cell signaling. While low in quantitative terms, this oxygen consumption, primarily from nicotinamide adenine dinucleotide phosphate oxidases and possibly by mitochondria, is very significant physiologically. Finally, we will briefly consider the role of enzymes involved with eliminating the toxic byproducts of the reactions listed above. Our primary aim here, however, is to describe the normal O2 metabolism of the lung.

Original languageEnglish
Title of host publicationComparative Biology of the Normal Lung: Second Edition
PublisherElsevier Inc.
Pages355-374
Number of pages20
ISBN (Electronic)9780124045774
ISBN (Print)9780124047266
DOIs
Publication statusPublished - 18 Mar 2015
Externally publishedYes

Fingerprint

Oxygen
Lung
Adenosine Triphosphate
Elastin
Leukotrienes
Poisons
Xenobiotics
Electron Transport Complex IV
Phagocytes
Mixed Function Oxygenases
NADP
Oxygen Consumption
Cytochrome P-450 Enzyme System
Hydrogen Peroxide
Energy Metabolism
Prostaglandins
Amines
Serotonin
Mitochondria
Oxidoreductases

Keywords

  • Antioxidants
  • Cytochrome P450
  • Dioxygenase
  • Mitochondria
  • Monooxygenase
  • Oxidase
  • Oxidoreductase
  • Peroxide signaling

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Gow, A. J., & Forman, H. J. (2015). Oxygen Metabolism in the Lung. In Comparative Biology of the Normal Lung: Second Edition (pp. 355-374). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-404577-4.00018-7

Oxygen Metabolism in the Lung. / Gow, Andrew J.; Forman, Henry J.

Comparative Biology of the Normal Lung: Second Edition. Elsevier Inc., 2015. p. 355-374.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gow, AJ & Forman, HJ 2015, Oxygen Metabolism in the Lung. in Comparative Biology of the Normal Lung: Second Edition. Elsevier Inc., pp. 355-374. https://doi.org/10.1016/B978-0-12-404577-4.00018-7
Gow AJ, Forman HJ. Oxygen Metabolism in the Lung. In Comparative Biology of the Normal Lung: Second Edition. Elsevier Inc. 2015. p. 355-374 https://doi.org/10.1016/B978-0-12-404577-4.00018-7
Gow, Andrew J. ; Forman, Henry J. / Oxygen Metabolism in the Lung. Comparative Biology of the Normal Lung: Second Edition. Elsevier Inc., 2015. pp. 355-374
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