Osteoinductive composite coatings for flexible intramedullary nails

E. N. Bolbasov, A. V. Popkov, D. A. Popkov, E. N. Gorbach, I. A. Khlusov, A. S. Golovkin, A. Sinev, V. M. Bouznik, S. I. Tverdokhlebov, Y. G. Anissimov

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Abstract

This work presents composite coatings based on a copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) for flexible intramedullary nails (FIN). The effect of the proportion of VDF-TeFE (100–25% wt.) on physicochemical and biological properties of the composite coatings was investigated. It was shown that a decrease of VDF-TeFE in the coating hinders its crystallization in β and γ forms which have piezoelectric properties. The decrease also reduces an adhesive strength to 9.9 ± 2.4 MPa and a relative elongation to 5.9 ± 1.2%, but results in increased osteogenesis. It was demonstrated that the composite coatings with 35% VDF-TeFE has the required combination of physicochemical properties and osteogenic activity. Comparative studies of composite coatings (35% VDF-TeFE) and calcium phosphate coatings produced using micro-arc oxidation, demonstrated comparable results for strength of bonding of these FINs with trabecular bones (~ 530 MPa). It was hypothesized that the high osteoinductive properties of the composite coatings are due to their piezoelectric properties.

Original languageEnglish
Pages (from-to)207-220
Number of pages14
JournalMaterials Science and Engineering C
Volume75
DOIs
Publication statusPublished - 1 Jun 2017

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Keywords

  • Flexible intramedullary nail
  • Hydroxyapatite
  • Piezoelectric
  • Vinylidene fluoride − tetrafluoroethylene copolymer

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Bolbasov, E. N., Popkov, A. V., Popkov, D. A., Gorbach, E. N., Khlusov, I. A., Golovkin, A. S., Sinev, A., Bouznik, V. M., Tverdokhlebov, S. I., & Anissimov, Y. G. (2017). Osteoinductive composite coatings for flexible intramedullary nails. Materials Science and Engineering C, 75, 207-220. https://doi.org/10.1016/j.msec.2017.02.073