Osteogenic and angiogenic properties of heparin as a system of biomolecule delivery for bone bioengineering: A brief critical review

L. S. Litvinova, K. A. Yurova, O. G. Khaziakhmatova, M. Y. Khlusova, V. V. Malashchenko, E. O. Shunkin, N. M. Todosenko, I. K. Norkin, P. A. Ivanov, I. A. Khlusov

Research output: Contribution to journalReview articlepeer-review

Abstract

The review discusses the complex, ambiguous and individual effects of heparin and its derivatives on the bone and circulatory systems, in dependence of the dosage, the state of the cells and tissues of recipients. General data on the anticoagulant activity of heparin and its derivatives are presented; aspects of the effect of heparin on mesenchymal cells and tissues and its role in angiogenesis are considered in details. Particular attention is paid to the ability of heparin to bind osteogenic and angiogenic biomolecules: This is especially important for the development of systems for their delivery and sustained controlled release. A schematic representation of the positive and side effects of heparin as a delivery system for biomolecules in tissue engineering is proposed.

Original languageEnglish
Pages (from-to)431-436
Number of pages6
JournalBiomeditsinskaya Khimiya
Volume66
Issue number6
DOIs
Publication statusPublished - 2021

Keywords

  • Anticoagulant
  • Bone tissue bioengineering
  • Delivery system
  • Hemostasis system
  • Heparin
  • Regenerative medicine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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