Osteointegration von titan-implantaten durch zugabe von rekombinantem bone morphogenetic protein 2 (rhBMP-2)

Translated title of the contribution: Osseointegration of titanium implants by addition of recombinant bone morphogenetic protein 2 (rhBMP-2)

T. K. Lichtinger, R. T. Müller, N. Schürmann, M. Oldenburg, M. Wiemann, M. Chatzinikolaidou, H. M. Rumpf, H. P. Jennissen

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The osseointegration of long-term implants is often incomplete such that gaps remain between the implant surface and the surrounding hard tissue. This study examines the effect of soluble recombinant human bone morphogenic protein 2 (rhBMP-2) on gap healing and osseous integration. The effect of a single, intraoperative application of soluble rhBMP-2 on the formation of new bone around titanium implants was studied. A total of 8 titanium-alloy cylinders (Ti-6A1-4V) with a plasma spray coating (TPS; 400 μm thickness) were implanted into femoral condyles of mature sheep: rhBMP-2 solution (1 μg) was pipetted into the 1 mm wide cleft around 4 implants; 4 further implants served as rhBMP-2-free controls. Two of these controls exhibited an additional calciumphosphate-coating. The cleft around the implants served as testing zone to study the formation of new bone by microradiographical and histological analyses. The follow-up periods were 4 and 9 weeks, respectively. A significant amount of new bone contacting the implants' surface was detected where rhBMP-2-solution had been used: In 50% a circumferential osseoinduction occurred within 4 weeks and a nearly complete osseointegration was observed after 9 weeks. In all cases bone formation was exaggerated and filled the spongiosa with compact bone. Time matched TPS-controls and controls with calciumphosphate coating showed no notable formation of new bone. The results suggest that a single administration of soluble rhBMP-2 into a bone cavity can augment bone formation and also osseointegration of titanium implants. Further investigations based on these findings are necessary to develop long-term implants (e. g. joint replacements) with rhBMP-2-biocoating for humans.

Translated title of the contributionOsseointegration of titanium implants by addition of recombinant bone morphogenetic protein 2 (rhBMP-2)
Original languageGerman
Pages (from-to)937-941
Number of pages5
JournalMaterialwissenschaft und Werkstofftechnik
Issue number12
Publication statusPublished - Dec 2001
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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