Abstract
Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.
| Original language | English |
|---|---|
| Pages (from-to) | 1339-1345 |
| Number of pages | 7 |
| Journal | Journal of Cerebral Blood Flow and Metabolism |
| Volume | 31 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2011 |
| Externally published | Yes |
Keywords
- hydrogen clearance
- optical coherence tomography
- optical imaging
- vascular biology
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Clinical Neurology
- Neurology
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Cite this
Srinivasan, V. J., Atochin, D. N., Radhakrishnan, H., Jiang, J. Y., Ruvinskaya, S., Wu, W., Barry, S., Cable, A. E., Ayata, C., Huang, P. L., & Boas, D. A. (2011). Optical coherence tomography for the quantitative study of cerebrovascular physiology. Journal of Cerebral Blood Flow and Metabolism, 31(6), 1339-1345. https://doi.org/10.1038/jcbfm.2011.19