Optical coherence tomography for the quantitative study of cerebrovascular physiology

Vivek J. Srinivasan, Dmitriy N. Atochin, Harsha Radhakrishnan, James Y. Jiang, Svetlana Ruvinskaya, Weicheng Wu, Scott Barry, Alex E. Cable, Cenk Ayata, Paul L. Huang, David A. Boas

Research output: Contribution to journal › Article

52 Citations (Scopus)

Abstract

Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

Original language	English
Pages (from-to)	1339-1345
Number of pages	7
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	31
Issue number	6
DOIs	https://doi.org/10.1038/jcbfm.2011.19
Publication status	Published - Jun 2011
Externally published	Yes

Fingerprint

Keywords

hydrogen clearance
optical coherence tomography
optical imaging
vascular biology

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Clinical Neurology
Neurology

Cite this

Srinivasan, V. J., Atochin, D. N., Radhakrishnan, H., Jiang, J. Y., Ruvinskaya, S., Wu, W., Barry, S., Cable, A. E., Ayata, C., Huang, P. L., & Boas, D. A. (2011). Optical coherence tomography for the quantitative study of cerebrovascular physiology. Journal of Cerebral Blood Flow and Metabolism, 31(6), 1339-1345. https://doi.org/10.1038/jcbfm.2011.19

Optical coherence tomography for the quantitative study of cerebrovascular physiology. / Srinivasan, Vivek J.; Atochin, Dmitriy N.; Radhakrishnan, Harsha; Jiang, James Y.; Ruvinskaya, Svetlana; Wu, Weicheng; Barry, Scott; Cable, Alex E.; Ayata, Cenk; Huang, Paul L.; Boas, David A.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 31, No. 6, 06.2011, p. 1339-1345.

Research output: Contribution to journal › Article

Srinivasan, Vivek J. ; Atochin, Dmitriy N. ; Radhakrishnan, Harsha ; Jiang, James Y. ; Ruvinskaya, Svetlana ; Wu, Weicheng ; Barry, Scott ; Cable, Alex E. ; Ayata, Cenk ; Huang, Paul L. ; Boas, David A. / Optical coherence tomography for the quantitative study of cerebrovascular physiology. In: Journal of Cerebral Blood Flow and Metabolism. 2011 ; Vol. 31, No. 6. pp. 1339-1345.

@article{f6a088aa3abc4fada2f2b1435e7e0764,

title = "Optical coherence tomography for the quantitative study of cerebrovascular physiology",

abstract = "Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.",

keywords = "hydrogen clearance, optical coherence tomography, optical imaging, vascular biology",

author = "Srinivasan, {Vivek J.} and Atochin, {Dmitriy N.} and Harsha Radhakrishnan and Jiang, {James Y.} and Svetlana Ruvinskaya and Weicheng Wu and Scott Barry and Cable, {Alex E.} and Cenk Ayata and Huang, {Paul L.} and Boas, {David A.}",

year = "2011",

month = jun

doi = "10.1038/jcbfm.2011.19",

language = "English",

volume = "31",

pages = "1339--1345",

journal = "Journal of Cerebral Blood Flow and Metabolism",

issn = "0271-678X",

publisher = "Nature Publishing Group",

number = "6",

}

TY - JOUR

T1 - Optical coherence tomography for the quantitative study of cerebrovascular physiology

AU - Srinivasan, Vivek J.

AU - Atochin, Dmitriy N.

AU - Radhakrishnan, Harsha

AU - Jiang, James Y.

AU - Ruvinskaya, Svetlana

AU - Wu, Weicheng

AU - Barry, Scott

AU - Cable, Alex E.

AU - Ayata, Cenk

AU - Huang, Paul L.

AU - Boas, David A.

PY - 2011/6

Y1 - 2011/6

N2 - Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

AB - Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

KW - hydrogen clearance

KW - optical coherence tomography

KW - optical imaging

KW - vascular biology

UR - http://www.scopus.com/inward/record.url?scp=79957941725&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957941725&partnerID=8YFLogxK

U2 - 10.1038/jcbfm.2011.19

DO - 10.1038/jcbfm.2011.19

M3 - Article

C2 - 21364599

AN - SCOPUS:79957941725

VL - 31

SP - 1339

EP - 1345

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 6

ER -

Access to Document

10.1038/jcbfm.2011.19