TY - JOUR
T1 - Optical coherence tomography for the quantitative study of cerebrovascular physiology
AU - Srinivasan, Vivek J.
AU - Atochin, Dmitriy N.
AU - Radhakrishnan, Harsha
AU - Jiang, James Y.
AU - Ruvinskaya, Svetlana
AU - Wu, Weicheng
AU - Barry, Scott
AU - Cable, Alex E.
AU - Ayata, Cenk
AU - Huang, Paul L.
AU - Boas, David A.
PY - 2011/6
Y1 - 2011/6
N2 - Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.
AB - Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.
KW - hydrogen clearance
KW - optical coherence tomography
KW - optical imaging
KW - vascular biology
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U2 - 10.1038/jcbfm.2011.19
DO - 10.1038/jcbfm.2011.19
M3 - Article
C2 - 21364599
AN - SCOPUS:79957941725
VL - 31
SP - 1339
EP - 1345
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 6
ER -