Optical coherence tomography for the quantitative study of cerebrovascular physiology

Abstract

Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

Original language	English
Pages (from-to)	1339-1345
Number of pages	7
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	31
Issue number	6
DOIs	https://doi.org/10.1038/jcbfm.2011.19
Publication status	Published - Jun 2011
Externally published	Yes

Keywords

hydrogen clearance
optical coherence tomography
optical imaging
vascular biology

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Clinical Neurology
Neurology

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10.1038/jcbfm.2011.19

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Optical coherence tomography for the quantitative study of cerebrovascular physiology. / Srinivasan, Vivek J.; Atochin, Dmitriy N.; Radhakrishnan, Harsha; Jiang, James Y.; Ruvinskaya, Svetlana; Wu, Weicheng; Barry, Scott; Cable, Alex E.; Ayata, Cenk; Huang, Paul L.; Boas, David A.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 31, No. 6, 06.2011, p. 1339-1345.

Research output: Contribution to journal › Article › peer-review

Srinivasan, Vivek J. ; Atochin, Dmitriy N. ; Radhakrishnan, Harsha ; Jiang, James Y. ; Ruvinskaya, Svetlana ; Wu, Weicheng ; Barry, Scott ; Cable, Alex E. ; Ayata, Cenk ; Huang, Paul L. ; Boas, David A. / Optical coherence tomography for the quantitative study of cerebrovascular physiology. In: Journal of Cerebral Blood Flow and Metabolism. 2011 ; Vol. 31, No. 6. pp. 1339-1345.

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