Abstract
Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.
| Original language | English |
|---|---|
| Pages (from-to) | 1339-1345 |
| Number of pages | 7 |
| Journal | Journal of Cerebral Blood Flow and Metabolism |
| Volume | 31 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2011 |
| Externally published | Yes |
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Keywords
- hydrogen clearance
- optical coherence tomography
- optical imaging
- vascular biology
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Clinical Neurology
- Neurology
Cite this
Optical coherence tomography for the quantitative study of cerebrovascular physiology. / Srinivasan, Vivek J.; Atochin, Dmitriy N.; Radhakrishnan, Harsha; Jiang, James Y.; Ruvinskaya, Svetlana; Wu, Weicheng; Barry, Scott; Cable, Alex E.; Ayata, Cenk; Huang, Paul L.; Boas, David A.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 31, No. 6, 06.2011, p. 1339-1345.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optical coherence tomography for the quantitative study of cerebrovascular physiology
AU - Srinivasan, Vivek J.
AU - Atochin, Dmitriy N.
AU - Radhakrishnan, Harsha
AU - Jiang, James Y.
AU - Ruvinskaya, Svetlana
AU - Wu, Weicheng
AU - Barry, Scott
AU - Cable, Alex E.
AU - Ayata, Cenk
AU - Huang, Paul L.
AU - Boas, David A.
PY - 2011/6
Y1 - 2011/6
N2 - Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.
AB - Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.
KW - hydrogen clearance
KW - optical coherence tomography
KW - optical imaging
KW - vascular biology
UR - http://www.scopus.com/inward/record.url?scp=79957941725&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957941725&partnerID=8YFLogxK
U2 - 10.1038/jcbfm.2011.19
DO - 10.1038/jcbfm.2011.19
M3 - Article
C2 - 21364599
AN - SCOPUS:79957941725
VL - 31
SP - 1339
EP - 1345
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 6
ER -