Optical coherence tomography for the quantitative study of cerebrovascular physiology

Vivek J. Srinivasan, Dmitriy N. Atochin, Harsha Radhakrishnan, James Y. Jiang, Svetlana Ruvinskaya, Weicheng Wu, Scott Barry, Alex E. Cable, Cenk Ayata, Paul L. Huang, David A. Boas

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

Original languageEnglish
Pages (from-to)1339-1345
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number6
Publication statusPublished - Jun 2011
Externally publishedYes


  • hydrogen clearance
  • optical coherence tomography
  • optical imaging
  • vascular biology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

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