We present detailed data on the role of central and peripheral opioid receptors in the regulation of heart resistance to arrhythmogenic factors. Stimulation of peripheral δ2- and κ1-receptors increases heart resistance to the arrhythmogenic effect of acute ischemia and reperfusion. Activation of peripheral μ- and δ1-opioid receptors improves electrical stability of the heart in animals with postinfarction cardiosclerosis. Possible mechanisms for opioidergic regulation of heart resistance to arrhythmogenic factors are discussed.
|Number of pages||6|
|Journal||Bulletin of Experimental Biology and Medicine|
|Publication status||Published - 1 Aug 2004|
- cardiac ischemia/reperfusion
- Opioid receptors
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)