Opiatergic mechanisms of the cardiotropic effect of acute cooling

Abstract

Changes in myocardial contractility after an acute cold exposure following intracerebroventricular administration of opiate receptor agonists were studied in rat hearts isolated after Langendorff. Cold exposures were carried out individually for each animal in chambers at -10°C for 4 h. Thirty min before being exposed to cold the animals were administered in a brain ventricle 10 μl of μ- or δ-opiate receptor agonists (DAGO or DADLE, respectively). Isolation and perfusion of the hearts were performed directly after the cold exposure was over. The mechanism of reduction of myocardial contractility and coronary flow induced by an acute cold exposure is believed to include stimulation of μ-opiate receptors as one of its main components, and the effect of intracerebral hypertension on hemodynamic parameters is partially mediated through activation of δ-opiate receptors.

Original language	English
Pages (from-to)	1273-1275
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	118
Issue number	6
DOIs	https://doi.org/10.1007/BF02445727
Publication status	Published - 1 Dec 1994

Keywords

cold exposure
contractility
isolated heart

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/BF02445727

Fingerprint Dive into the research topics of 'Opiatergic mechanisms of the cardiotropic effect of acute cooling'. Together they form a unique fingerprint.

Cite this

@article{0708be3a13764e1883d0ab3e08a56372,

title = "Opiatergic mechanisms of the cardiotropic effect of acute cooling",

abstract = "Changes in myocardial contractility after an acute cold exposure following intracerebroventricular administration of opiate receptor agonists were studied in rat hearts isolated after Langendorff. Cold exposures were carried out individually for each animal in chambers at -10°C for 4 h. Thirty min before being exposed to cold the animals were administered in a brain ventricle 10 μl of μ- or δ-opiate receptor agonists (DAGO or DADLE, respectively). Isolation and perfusion of the hearts were performed directly after the cold exposure was over. The mechanism of reduction of myocardial contractility and coronary flow induced by an acute cold exposure is believed to include stimulation of μ-opiate receptors as one of its main components, and the effect of intracerebral hypertension on hemodynamic parameters is partially mediated through activation of δ-opiate receptors.",

keywords = "cold exposure, contractility, isolated heart",

author = "Afanas'ev, {S. A.} and Alekseeva, {E. D.} and Lishmanov, {Yu B.}",

year = "1994",

month = dec,

day = "1",

doi = "10.1007/BF02445727",

language = "English",

volume = "118",

pages = "1273--1275",

journal = "Bulletin of Experimental Biology and Medicine",

issn = "0007-4888",

publisher = "Springer New York",

number = "6",

}

TY - JOUR

T1 - Opiatergic mechanisms of the cardiotropic effect of acute cooling

AU - Afanas'ev, S. A.

AU - Alekseeva, E. D.

AU - Lishmanov, Yu B.

PY - 1994/12/1

Y1 - 1994/12/1

N2 - Changes in myocardial contractility after an acute cold exposure following intracerebroventricular administration of opiate receptor agonists were studied in rat hearts isolated after Langendorff. Cold exposures were carried out individually for each animal in chambers at -10°C for 4 h. Thirty min before being exposed to cold the animals were administered in a brain ventricle 10 μl of μ- or δ-opiate receptor agonists (DAGO or DADLE, respectively). Isolation and perfusion of the hearts were performed directly after the cold exposure was over. The mechanism of reduction of myocardial contractility and coronary flow induced by an acute cold exposure is believed to include stimulation of μ-opiate receptors as one of its main components, and the effect of intracerebral hypertension on hemodynamic parameters is partially mediated through activation of δ-opiate receptors.

AB - Changes in myocardial contractility after an acute cold exposure following intracerebroventricular administration of opiate receptor agonists were studied in rat hearts isolated after Langendorff. Cold exposures were carried out individually for each animal in chambers at -10°C for 4 h. Thirty min before being exposed to cold the animals were administered in a brain ventricle 10 μl of μ- or δ-opiate receptor agonists (DAGO or DADLE, respectively). Isolation and perfusion of the hearts were performed directly after the cold exposure was over. The mechanism of reduction of myocardial contractility and coronary flow induced by an acute cold exposure is believed to include stimulation of μ-opiate receptors as one of its main components, and the effect of intracerebral hypertension on hemodynamic parameters is partially mediated through activation of δ-opiate receptors.

KW - cold exposure

KW - contractility

KW - isolated heart

UR - http://www.scopus.com/inward/record.url?scp=51649138031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51649138031&partnerID=8YFLogxK

U2 - 10.1007/BF02445727

DO - 10.1007/BF02445727

M3 - Article

AN - SCOPUS:51649138031

VL - 118

SP - 1273

EP - 1275

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 6