Abstract
Changes in myocardial contractility after an acute cold exposure following intracerebroventricular administration of opiate receptor agonists were studied in rat hearts isolated after Langendorff. Cold exposures were carried out individually for each animal in chambers at -10°C for 4 h. Thirty min before being exposed to cold the animals were administered in a brain ventricle 10 μl of μ- or δ-opiate receptor agonists (DAGO or DADLE, respectively). Isolation and perfusion of the hearts were performed directly after the cold exposure was over. The mechanism of reduction of myocardial contractility and coronary flow induced by an acute cold exposure is believed to include stimulation of μ-opiate receptors as one of its main components, and the effect of intracerebral hypertension on hemodynamic parameters is partially mediated through activation of δ-opiate receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 1273-1275 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 118 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Dec 1994 |
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Keywords
- cold exposure
- contractility
- isolated heart
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Opiatergic mechanisms of the cardiotropic effect of acute cooling. / Afanas'ev, S. A.; Alekseeva, E. D.; Lishmanov, Yu B.
In: Bulletin of Experimental Biology and Medicine, Vol. 118, No. 6, 01.12.1994, p. 1273-1275.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Opiatergic mechanisms of the cardiotropic effect of acute cooling
AU - Afanas'ev, S. A.
AU - Alekseeva, E. D.
AU - Lishmanov, Yu B.
PY - 1994/12/1
Y1 - 1994/12/1
N2 - Changes in myocardial contractility after an acute cold exposure following intracerebroventricular administration of opiate receptor agonists were studied in rat hearts isolated after Langendorff. Cold exposures were carried out individually for each animal in chambers at -10°C for 4 h. Thirty min before being exposed to cold the animals were administered in a brain ventricle 10 μl of μ- or δ-opiate receptor agonists (DAGO or DADLE, respectively). Isolation and perfusion of the hearts were performed directly after the cold exposure was over. The mechanism of reduction of myocardial contractility and coronary flow induced by an acute cold exposure is believed to include stimulation of μ-opiate receptors as one of its main components, and the effect of intracerebral hypertension on hemodynamic parameters is partially mediated through activation of δ-opiate receptors.
AB - Changes in myocardial contractility after an acute cold exposure following intracerebroventricular administration of opiate receptor agonists were studied in rat hearts isolated after Langendorff. Cold exposures were carried out individually for each animal in chambers at -10°C for 4 h. Thirty min before being exposed to cold the animals were administered in a brain ventricle 10 μl of μ- or δ-opiate receptor agonists (DAGO or DADLE, respectively). Isolation and perfusion of the hearts were performed directly after the cold exposure was over. The mechanism of reduction of myocardial contractility and coronary flow induced by an acute cold exposure is believed to include stimulation of μ-opiate receptors as one of its main components, and the effect of intracerebral hypertension on hemodynamic parameters is partially mediated through activation of δ-opiate receptors.
KW - cold exposure
KW - contractility
KW - isolated heart
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UR - http://www.scopus.com/inward/citedby.url?scp=51649138031&partnerID=8YFLogxK
U2 - 10.1007/BF02445727
DO - 10.1007/BF02445727
M3 - Article
AN - SCOPUS:51649138031
VL - 118
SP - 1273
EP - 1275
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 6
ER -