Opiatergic mechanisms of the antiarrhythmic effect of adaptation

Yu B. Lishmanov, E. V. Uskina, L. N. Maslov, A. V. Krylatov

Research output: Contribution to journalArticlepeer-review


A decrease in the severity and occurrence of epinephrine- and CaCl2-induced cardiac arrhythmias and an increase in the β-endorphin and enkephalin contents in the brain, myocardium, adrenals, and blood plasma are observed in rats adapted to stress. The antiarrhythmic effect of adaptation is abolished by naloxone. A single administration of D-kyotorphin, a liberator of endogenous peptides, to intact animals also increases the resistance to arrhythmogenic factors. Intravenous administration of the enkephalinase inhibitor RB101 produces a significant antiarrhythmic effect in control animals.

Original languageEnglish
Pages (from-to)892-894
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Issue number3
Publication statusPublished - Sep 1996


  • adaptation
  • arrhythmia
  • opiate receptors
  • opioid peptides
  • stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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