A decrease in the severity and occurrence of epinephrine- and CaCl2-induced cardiac arrhythmias and an increase in the β-endorphin and enkephalin contents in the brain, myocardium, adrenals, and blood plasma are observed in rats adapted to stress. The antiarrhythmic effect of adaptation is abolished by naloxone. A single administration of D-kyotorphin, a liberator of endogenous peptides, to intact animals also increases the resistance to arrhythmogenic factors. Intravenous administration of the enkephalinase inhibitor RB101 produces a significant antiarrhythmic effect in control animals.
- opiate receptors
- opioid peptides
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)