Opiatergic mechanisms of the antiarrhythmic effect of adaptation

Yu B. Lishmanov, E. V. Uskina, L. N. Maslov, A. V. Krylatov

Research output: Contribution to journalArticle

Abstract

A decrease in the severity and occurrence of epinephrine- and CaCl2-induced cardiac arrhythmias and an increase in the β-endorphin and enkephalin contents in the brain, myocardium, adrenals, and blood plasma are observed in rats adapted to stress. The antiarrhythmic effect of adaptation is abolished by naloxone. A single administration of D-kyotorphin, a liberator of endogenous peptides, to intact animals also increases the resistance to arrhythmogenic factors. Intravenous administration of the enkephalinase inhibitor RB101 produces a significant antiarrhythmic effect in control animals.

Original languageEnglish
Pages (from-to)892-894
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume122
Issue number3
DOIs
Publication statusPublished - Sep 1996

Fingerprint

kyotorphin
Animals
Endorphins
Neprilysin
Enkephalins
Naloxone
Intravenous Administration
Epinephrine
Rats
Cardiac Arrhythmias
Brain
Myocardium
Blood
Plasmas
Peptides
RB 101

Keywords

  • adaptation
  • arrhythmia
  • opiate receptors
  • opioid peptides
  • stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Opiatergic mechanisms of the antiarrhythmic effect of adaptation. / Lishmanov, Yu B.; Uskina, E. V.; Maslov, L. N.; Krylatov, A. V.

In: Bulletin of Experimental Biology and Medicine, Vol. 122, No. 3, 09.1996, p. 892-894.

Research output: Contribution to journalArticle

Lishmanov, Yu B. ; Uskina, E. V. ; Maslov, L. N. ; Krylatov, A. V. / Opiatergic mechanisms of the antiarrhythmic effect of adaptation. In: Bulletin of Experimental Biology and Medicine. 1996 ; Vol. 122, No. 3. pp. 892-894.
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