Opiatergic mechanisms of cardioprotective and antiarrhythmic effects of adaptation

Yu B. Lishmanov, L. A. Maimeskulova, E. V. Uskina, L. N. Maslov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Adaptation to hypoxia and short-term immobilization stress, as well as preconditioning with Rhodiolae rosea extract produces pronounced antiarrhythmic and cardioprotective effects in the model of adrenergic damage to the heart. Preliminary blockade of opioid receptor significantly decreases the protective effect of adaptation. Using selective opiate receptor antagonists (naltrindole, ICI 174,864, and norbinaltorphimine) we show that the antiarrhythmic effect of adaptation is mediated predominantly via activation of κ-receptors, and to a lesser extent μ- and δ-receptors.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume127
Issue number2
Publication statusPublished - Feb 1999

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Keywords

  • Adaptation
  • Isoproterenol-induced damage
  • Myocardium
  • Opiatergic system

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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