Adaptation to hypoxia and short-term immobilization stress, as well as preconditioning with Rhodiolae rosea extract produces pronounced antiarrhythmic and cardioprotective effects in the model of adrenergic damage to the heart. Preliminary blockade of opioid receptor significantly decreases the protective effect of adaptation. Using selective opiate receptor antagonists (naltrindole, ICI 174,864, and norbinaltorphimine) we show that the antiarrhythmic effect of adaptation is mediated predominantly via activation of κ-receptors, and to a lesser extent μ- and δ-receptors.
|Number of pages||4|
|Journal||Bulletin of Experimental Biology and Medicine|
|Publication status||Published - Feb 1999|
- Isoproterenol-induced damage
- Opiatergic system
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)