"On water": Unique reactivity of organic compounds in aqueous suspension

Sridhar Narayan, John Muldoon, M. G. Finn, Valery V. Fokin, Hartmuth C. Kolb, K. Barry Sharpless

Research output: Contribution to journalArticlepeer-review

1258 Citations (Scopus)

Abstract

(Chemical Equation Presented) Water, the medium of choice: Many reactions, such as Claisen rearrangements (see scheme), are dramatically accelerated when performed in aqueous suspension ("on water") relative to organic (Table Presented) solvents or even neat conditions. Low miscibility of organic compounds with water is not detrimental: in fact, it facilitates the isolation of products.

Original languageEnglish
Pages (from-to)3275-3279
Number of pages5
JournalAngewandte Chemie - International Edition
Volume44
Issue number21
DOIs
Publication statusPublished - 20 May 2005
Externally publishedYes

Keywords

  • Click chemistry
  • Cycloaddition
  • Interfaces
  • Rearrangement
  • Water chemistry

ASJC Scopus subject areas

  • Chemistry(all)

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