On the diverse outcomes of base-induced cyclisations of 2-alkynylphenylhydroxamic acids

David W. Knight, Paul B.M. Lewis, K. M. Abdul Malik, Elena V. Mshvidobadze, Sergei F. Vasilevsky

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9 Citations (Scopus)


Base-induced cyclisations of 2-alkynylphenylhydroxamic acids occur by attack of nitrogen onto the alkyne group in either exo or endo fashions to give the corresponding isoindol-1(2H)-ones or 1(2H)-isoquinolinones depending upon the alkyne substituent.

Original languageEnglish
Pages (from-to)9187-9189
Number of pages3
JournalTetrahedron Letters
Issue number50
Publication statusPublished - 9 Dec 2002
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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