On the diverse outcomes of base-induced cyclisations of 2-alkynylphenylhydroxamic acids

David W. Knight, Paul B.M. Lewis, K. M. Abdul Malik, Elena V. Mshvidobadze, Sergei F. Vasilevsky

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Base-induced cyclisations of 2-alkynylphenylhydroxamic acids occur by attack of nitrogen onto the alkyne group in either exo or endo fashions to give the corresponding isoindol-1(2H)-ones or 1(2H)-isoquinolinones depending upon the alkyne substituent.

Original languageEnglish
Pages (from-to)9187-9189
Number of pages3
JournalTetrahedron Letters
Volume43
Issue number50
DOIs
Publication statusPublished - 9 Dec 2002
Externally publishedYes

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Alkynes
Cyclization
Acids
Nitrogen
Isoindol-1-one

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

On the diverse outcomes of base-induced cyclisations of 2-alkynylphenylhydroxamic acids. / Knight, David W.; Lewis, Paul B.M.; Abdul Malik, K. M.; Mshvidobadze, Elena V.; Vasilevsky, Sergei F.

In: Tetrahedron Letters, Vol. 43, No. 50, 09.12.2002, p. 9187-9189.

Research output: Contribution to journalArticle

Knight, David W. ; Lewis, Paul B.M. ; Abdul Malik, K. M. ; Mshvidobadze, Elena V. ; Vasilevsky, Sergei F. / On the diverse outcomes of base-induced cyclisations of 2-alkynylphenylhydroxamic acids. In: Tetrahedron Letters. 2002 ; Vol. 43, No. 50. pp. 9187-9189.
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