Oenothein B, a Cyclic Dimeric Ellagitannin Isolated from Epilobium angustifolium, Enhances IFNγ Production by Lymphocytes

Andrew G. Ramstead, Igor A. Schepetkin, Mark T. Quinn, Mark A. Jutila

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Oenothein B is a polyphenol isolated from Epilobium angustifolium and other plant sources, which has been reported to exhibit immunomodulatory properties. Oenothein B is known to activate myeloid cells and induce the production of IL-1 and other cytokines. However, its effects on lymphocytes are unknown. In this report, we show that oenothein B stimulated innate lymphocytes, including bovine and human γδ T cells and NK cells, resulting in either increased CD25 and/or CD69 expression. We also demonstrate that oenothein B enhanced the production of interferon-γ (IFNγ) by bovine and human NK cells alone and in combination with interleukin-18 (IL-18), a response not observed with other commonly studied polyphenols. Furthermore, we demonstrate that oenothein B enhanced the production of IFNγ by human T cells. Since IFNγ contributes to antitumor, antibacterial, and antiviral cell responses, these data suggest an additional mechanism that could account, at least in part, for the immune enhancing properties of oenothein B.

Original languageEnglish
Article numbere50546
JournalPLoS One
Volume7
Issue number11
DOIs
Publication statusPublished - 30 Nov 2012
Externally publishedYes

Fingerprint

Epilobium
Epilobium angustifolium
Lymphocytes
interferons
Interferons
lymphocytes
natural killer cells
polyphenols
T-lymphocytes
interleukin-18
T-cells
cattle
interleukin-1
Polyphenols
Natural Killer Cells
cytokines
cells
T-Lymphocytes
Interleukin-18
Myeloid Cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Oenothein B, a Cyclic Dimeric Ellagitannin Isolated from Epilobium angustifolium, Enhances IFNγ Production by Lymphocytes. / Ramstead, Andrew G.; Schepetkin, Igor A.; Quinn, Mark T.; Jutila, Mark A.

In: PLoS One, Vol. 7, No. 11, e50546, 30.11.2012.

Research output: Contribution to journalArticle

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