Novel chemoselective 18F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions

Aristeidis Chiotellis, Filippo Sladojevich, Linjing Mu, Adrienne Müller Herde, Ibai E. Valverde, Vladimir Tolmachev, Roger Schibli, Simon M. Ametamey, Thomas L. Mindt

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective 18F-labeling of thiol-containing (bio)molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.

Original languageEnglish
Pages (from-to)6083-6086
Number of pages4
JournalChemical Communications
Volume52
Issue number36
DOIs
Publication statusPublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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