Novel chemical and electrochemical methods of synthesis of o-fluorobenzoic acid and others fluoroorganic compounds

A. P. Murlushev, S. N. Loshkomoev, Y. Ya Tomash, Y. F. Kobzar, I. I. Zherin, G. A. Arbit, V. D. Filimonov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

ortho-Fluorbenzoic acid (FBA) is useful product for organic syntheses and preparation of some medicines. We have elaborated the following effective chemical methods for synthesis of FBA. i) Nucleophilic substitution of o-chlorobenzoic acid by action of KF in the presence of the crown-ethers or inter-phase catalysis; ii) Reaction of anthranilic acid with NaNO2 into liquid HF with following thermal decomposition of the resulted diazonium salt at 100°C; iii) Fluorodecarboxilation of phthalic acid or its anhydride by heating in benzene in the presence of Pb(OAc)4 and CaF2. Also we have designed and produced of a special reactor for an electrochemical fluorination of various organic compounds.

Original languageEnglish
Title of host publicationProceedings - KORUS 2000: 4th Korea-Russia International Symposium on Science and Technology
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages173-175
Number of pages3
Volume1
ISBN (Print)0780364864, 9780780364868
DOIs
Publication statusPublished - 2000
Event4th Korea-Russia International Symposium on Science and Technology, KORUS 2000 - Ulsan, Korea, Republic of
Duration: 27 Jun 20001 Jul 2000

Other

Other4th Korea-Russia International Symposium on Science and Technology, KORUS 2000
CountryKorea, Republic of
CityUlsan
Period27.6.001.7.00

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Keywords

  • electrosynthesis
  • fluorbenzoic acid
  • fluorination

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Computer Networks and Communications
  • Biotechnology
  • Civil and Structural Engineering
  • Mechanics of Materials
  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Surfaces, Coatings and Films

Cite this

Murlushev, A. P., Loshkomoev, S. N., Tomash, Y. Y., Kobzar, Y. F., Zherin, I. I., Arbit, G. A., & Filimonov, V. D. (2000). Novel chemical and electrochemical methods of synthesis of o-fluorobenzoic acid and others fluoroorganic compounds. In Proceedings - KORUS 2000: 4th Korea-Russia International Symposium on Science and Technology (Vol. 1, pp. 173-175). [865945] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/KORUS.2000.865945