Novel chemical and electrochemical methods of synthesis of o-fluorobenzoic acid and others fluoroorganic compounds

A. P. Murlushev, S. N. Loshkomoev, Y. Ya Tomash, Y. F. Kobzar, I. I. Zherin, G. A. Arbit, V. D. Filimonov

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

ortho-Fluorbenzoic acid (FBA) is useful product for organic syntheses and preparation of some medicines. We have elaborated the following effective chemical methods for synthesis of FBA. i) Nucleophilic substitution of o-chlorobenzoic acid by action of KF in the presence of the crown-ethers or inter-phase catalysis; ii) Reaction of anthranilic acid with NaNO₂ into liquid HF with following thermal decomposition of the resulted diazonium salt at 100°C; iii) Fluorodecarboxilation of phthalic acid or its anhydride by heating in benzene in the presence of Pb(OAc)₄ and CaF₂. Also we have designed and produced of a special reactor for an electrochemical fluorination of various organic compounds.

Original language	English
Title of host publication	Proceedings - KORUS 2000: 4th Korea-Russia International Symposium on Science and Technology
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	173-175
Number of pages	3
Volume	1
ISBN (Print)	0780364864, 9780780364868
DOIs	https://doi.org/10.1109/KORUS.2000.865945
Publication status	Published - 2000
Event	4th Korea-Russia International Symposium on Science and Technology, KORUS 2000 - Ulsan, Korea, Republic of Duration: 27 Jun 2000 → 1 Jul 2000

Other

Other	4th Korea-Russia International Symposium on Science and Technology, KORUS 2000
Country	Korea, Republic of
City	Ulsan
Period	27.6.00 → 1.7.00

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Keywords

electrosynthesis
fluorbenzoic acid
fluorination

ASJC Scopus subject areas

Clinical Biochemistry
Computer Networks and Communications
Biotechnology
Civil and Structural Engineering
Mechanics of Materials
Electronic, Optical and Magnetic Materials
Materials Chemistry
Surfaces, Coatings and Films

Cite this

Murlushev, A. P., Loshkomoev, S. N., Tomash, Y. Y., Kobzar, Y. F., Zherin, I. I., Arbit, G. A., & Filimonov, V. D. (2000). Novel chemical and electrochemical methods of synthesis of o-fluorobenzoic acid and others fluoroorganic compounds. In Proceedings - KORUS 2000: 4th Korea-Russia International Symposium on Science and Technology (Vol. 1, pp. 173-175). [865945] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/KORUS.2000.865945

Novel chemical and electrochemical methods of synthesis of o-fluorobenzoic acid and others fluoroorganic compounds. / Murlushev, A. P.; Loshkomoev, S. N.; Tomash, Y. Ya; Kobzar, Y. F.; Zherin, I. I.; Arbit, G. A.; Filimonov, V. D.

Proceedings - KORUS 2000: 4th Korea-Russia International Symposium on Science and Technology. Vol. 1 Institute of Electrical and Electronics Engineers Inc., 2000. p. 173-175 865945.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Murlushev, AP, Loshkomoev, SN, Tomash, YY, Kobzar, YF, Zherin, II, Arbit, GA & Filimonov, VD 2000, Novel chemical and electrochemical methods of synthesis of o-fluorobenzoic acid and others fluoroorganic compounds. in Proceedings - KORUS 2000: 4th Korea-Russia International Symposium on Science and Technology. vol. 1, 865945, Institute of Electrical and Electronics Engineers Inc., pp. 173-175, 4th Korea-Russia International Symposium on Science and Technology, KORUS 2000, Ulsan, Korea, Republic of, 27.6.00. https://doi.org/10.1109/KORUS.2000.865945

Murlushev AP, Loshkomoev SN, Tomash YY, Kobzar YF, Zherin II, Arbit GA et al. Novel chemical and electrochemical methods of synthesis of o-fluorobenzoic acid and others fluoroorganic compounds. In Proceedings - KORUS 2000: 4th Korea-Russia International Symposium on Science and Technology. Vol. 1. Institute of Electrical and Electronics Engineers Inc. 2000. p. 173-175. 865945 https://doi.org/10.1109/KORUS.2000.865945

Murlushev, A. P. ; Loshkomoev, S. N. ; Tomash, Y. Ya ; Kobzar, Y. F. ; Zherin, I. I. ; Arbit, G. A. ; Filimonov, V. D. / Novel chemical and electrochemical methods of synthesis of o-fluorobenzoic acid and others fluoroorganic compounds. Proceedings - KORUS 2000: 4th Korea-Russia International Symposium on Science and Technology. Vol. 1 Institute of Electrical and Electronics Engineers Inc., 2000. pp. 173-175

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abstract = "ortho-Fluorbenzoic acid (FBA) is useful product for organic syntheses and preparation of some medicines. We have elaborated the following effective chemical methods for synthesis of FBA. i) Nucleophilic substitution of o-chlorobenzoic acid by action of KF in the presence of the crown-ethers or inter-phase catalysis; ii) Reaction of anthranilic acid with NaNO2 into liquid HF with following thermal decomposition of the resulted diazonium salt at 100°C; iii) Fluorodecarboxilation of phthalic acid or its anhydride by heating in benzene in the presence of Pb(OAc)4 and CaF2. Also we have designed and produced of a special reactor for an electrochemical fluorination of various organic compounds.",

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AU - Murlushev, A. P.

AU - Loshkomoev, S. N.

AU - Tomash, Y. Ya

AU - Kobzar, Y. F.

AU - Zherin, I. I.

AU - Arbit, G. A.

AU - Filimonov, V. D.

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AB - ortho-Fluorbenzoic acid (FBA) is useful product for organic syntheses and preparation of some medicines. We have elaborated the following effective chemical methods for synthesis of FBA. i) Nucleophilic substitution of o-chlorobenzoic acid by action of KF in the presence of the crown-ethers or inter-phase catalysis; ii) Reaction of anthranilic acid with NaNO2 into liquid HF with following thermal decomposition of the resulted diazonium salt at 100°C; iii) Fluorodecarboxilation of phthalic acid or its anhydride by heating in benzene in the presence of Pb(OAc)4 and CaF2. Also we have designed and produced of a special reactor for an electrochemical fluorination of various organic compounds.

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KW - fluorbenzoic acid

KW - fluorination

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BT - Proceedings - KORUS 2000: 4th Korea-Russia International Symposium on Science and Technology

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Access to Document

10.1109/KORUS.2000.865945