Abstract
The solution blow spinning is presented as a method of obtaining tissue engineering scaffolds. The different forming modes were used and the optimum experimental conditions were found. It is shown that nonwoven polylactide scaffolds with required surface morphology can be obtained. These samples were studied in case of biodegradation in simulation body fluid. It was found that during scaffold dissolution the pH of the solution changes insignificantly (6.85) despite the exponential increase of the monomers of lactic acid. The calcium and phosphorus ion exchange between the scaffold and solution was observed in the surface and bulk of the material what makes possible to use scaffolds for regenerative medicine.
| Original language | English |
|---|---|
| Title of host publication | Nanomaterials for Structural, Functional and Biomedical Applications |
| Pages | 257-262 |
| Number of pages | 6 |
| DOIs | |
| Publication status | Published - 15 Jan 2014 |
| Event | Russian-German Forum on Nanotechnology - Tomsk, Russian Federation Duration: 21 May 2013 → 24 May 2013 |
Publication series
| Name | Advanced Materials Research |
|---|---|
| Volume | 872 |
| ISSN (Print) | 1022-6680 |
Other
| Other | Russian-German Forum on Nanotechnology |
|---|---|
| Country | Russian Federation |
| City | Tomsk |
| Period | 21.5.13 → 24.5.13 |
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Keywords
- Biodegradation
- In vitro
- Polylactic acide
- Polymer scaffold
- Simulation body fluid
- Solution blow spinning
ASJC Scopus subject areas
- Engineering(all)
Cite this
Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics. / Tverdokhlebov, Sergei; Stankevich, Ksenia Sergeevna; Bolbasov, Evgeny; Khlusov, Igor Albertovich; Kulagina, Irina; Zaitsev, Konstantin.
Nanomaterials for Structural, Functional and Biomedical Applications. 2014. p. 257-262 (Advanced Materials Research; Vol. 872).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics
AU - Tverdokhlebov, Sergei
AU - Stankevich, Ksenia Sergeevna
AU - Bolbasov, Evgeny
AU - Khlusov, Igor Albertovich
AU - Kulagina, Irina
AU - Zaitsev, Konstantin
PY - 2014/1/15
Y1 - 2014/1/15
N2 - The solution blow spinning is presented as a method of obtaining tissue engineering scaffolds. The different forming modes were used and the optimum experimental conditions were found. It is shown that nonwoven polylactide scaffolds with required surface morphology can be obtained. These samples were studied in case of biodegradation in simulation body fluid. It was found that during scaffold dissolution the pH of the solution changes insignificantly (6.85) despite the exponential increase of the monomers of lactic acid. The calcium and phosphorus ion exchange between the scaffold and solution was observed in the surface and bulk of the material what makes possible to use scaffolds for regenerative medicine.
AB - The solution blow spinning is presented as a method of obtaining tissue engineering scaffolds. The different forming modes were used and the optimum experimental conditions were found. It is shown that nonwoven polylactide scaffolds with required surface morphology can be obtained. These samples were studied in case of biodegradation in simulation body fluid. It was found that during scaffold dissolution the pH of the solution changes insignificantly (6.85) despite the exponential increase of the monomers of lactic acid. The calcium and phosphorus ion exchange between the scaffold and solution was observed in the surface and bulk of the material what makes possible to use scaffolds for regenerative medicine.
KW - Biodegradation
KW - In vitro
KW - Polylactic acide
KW - Polymer scaffold
KW - Simulation body fluid
KW - Solution blow spinning
UR - http://www.scopus.com/inward/record.url?scp=84891892921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891892921&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMR.872.257
DO - 10.4028/www.scientific.net/AMR.872.257
M3 - Conference contribution
AN - SCOPUS:84891892921
SN - 9783037859667
T3 - Advanced Materials Research
SP - 257
EP - 262
BT - Nanomaterials for Structural, Functional and Biomedical Applications
ER -