Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics

Abstract

The solution blow spinning is presented as a method of obtaining tissue engineering scaffolds. The different forming modes were used and the optimum experimental conditions were found. It is shown that nonwoven polylactide scaffolds with required surface morphology can be obtained. These samples were studied in case of biodegradation in simulation body fluid. It was found that during scaffold dissolution the pH of the solution changes insignificantly (6.85) despite the exponential increase of the monomers of lactic acid. The calcium and phosphorus ion exchange between the scaffold and solution was observed in the surface and bulk of the material what makes possible to use scaffolds for regenerative medicine.

Original language	English
Title of host publication	Nanomaterials for Structural, Functional and Biomedical Applications
Pages	257-262
Number of pages	6
DOIs	https://doi.org/10.4028/www.scientific.net/AMR.872.257
Publication status	Published - 15 Jan 2014
Event	Russian-German Forum on Nanotechnology - Tomsk, Russian Federation Duration: 21 May 2013 → 24 May 2013

Publication series

Name	Advanced Materials Research
Volume	872
ISSN (Print)	1022-6680

Other

Other	Russian-German Forum on Nanotechnology
Country	Russian Federation
City	Tomsk
Period	21.5.13 → 24.5.13

Keywords

Biodegradation
In vitro
Polylactic acide
Polymer scaffold
Simulation body fluid
Solution blow spinning

ASJC Scopus subject areas

Engineering(all)

Access to Document

10.4028/www.scientific.net/AMR.872.257

Fingerprint Dive into the research topics of 'Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics'. Together they form a unique fingerprint.

Cite this

Tverdokhlebov, S., Stankevich, KS., Bolbasov, E., Khlusov, IA., Kulagina, I., & Zaitsev, K. (2014). Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics. In Nanomaterials for Structural, Functional and Biomedical Applications (pp. 257-262). (Advanced Materials Research; Vol. 872). https://doi.org/10.4028/www.scientific.net/AMR.872.257

Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics. / Tverdokhlebov, Sergei; Stankevich, Ksenia Sergeevna; Bolbasov, Evgeny ; Khlusov, Igor Albertovich; Kulagina, Irina; Zaitsev, Konstantin.

Nanomaterials for Structural, Functional and Biomedical Applications. 2014. p. 257-262 (Advanced Materials Research; Vol. 872).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Tverdokhlebov, S, Stankevich, KS, Bolbasov, E , Khlusov, IA, Kulagina, I & Zaitsev, K 2014, Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics. in Nanomaterials for Structural, Functional and Biomedical Applications. Advanced Materials Research, vol. 872, pp. 257-262, Russian-German Forum on Nanotechnology, Tomsk, Russian Federation, 21.5.13. https://doi.org/10.4028/www.scientific.net/AMR.872.257

Tverdokhlebov, Sergei ; Stankevich, Ksenia Sergeevna ; Bolbasov, Evgeny ; Khlusov, Igor Albertovich ; Kulagina, Irina ; Zaitsev, Konstantin. / Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics. Nanomaterials for Structural, Functional and Biomedical Applications. 2014. pp. 257-262 (Advanced Materials Research).

@inproceedings{7776d59509c44e9d8102bfa20f69bc05,

title = "Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics",

abstract = "The solution blow spinning is presented as a method of obtaining tissue engineering scaffolds. The different forming modes were used and the optimum experimental conditions were found. It is shown that nonwoven polylactide scaffolds with required surface morphology can be obtained. These samples were studied in case of biodegradation in simulation body fluid. It was found that during scaffold dissolution the pH of the solution changes insignificantly (6.85) despite the exponential increase of the monomers of lactic acid. The calcium and phosphorus ion exchange between the scaffold and solution was observed in the surface and bulk of the material what makes possible to use scaffolds for regenerative medicine.",

keywords = "Biodegradation, In vitro, Polylactic acide, Polymer scaffold, Simulation body fluid, Solution blow spinning",

author = "Sergei Tverdokhlebov and Ksenia Sergeevna Stankevich and Evgeny Bolbasov and Igor Albertovich Khlusov and Irina Kulagina and Konstantin Zaitsev",

year = "2014",

month = jan,

day = "15",

doi = "10.4028/www.scientific.net/AMR.872.257",

language = "English",

isbn = "9783037859667",

series = "Advanced Materials Research",

pages = "257--262",

booktitle = "Nanomaterials for Structural, Functional and Biomedical Applications",

note = "Russian-German Forum on Nanotechnology ; Conference date: 21-05-2013 Through 24-05-2013",

}

TY - GEN

T1 - Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics

AU - Tverdokhlebov, Sergei

AU - Stankevich, Ksenia Sergeevna

AU - Bolbasov, Evgeny

AU - Khlusov, Igor Albertovich

AU - Kulagina, Irina

AU - Zaitsev, Konstantin

PY - 2014/1/15

Y1 - 2014/1/15

N2 - The solution blow spinning is presented as a method of obtaining tissue engineering scaffolds. The different forming modes were used and the optimum experimental conditions were found. It is shown that nonwoven polylactide scaffolds with required surface morphology can be obtained. These samples were studied in case of biodegradation in simulation body fluid. It was found that during scaffold dissolution the pH of the solution changes insignificantly (6.85) despite the exponential increase of the monomers of lactic acid. The calcium and phosphorus ion exchange between the scaffold and solution was observed in the surface and bulk of the material what makes possible to use scaffolds for regenerative medicine.

AB - The solution blow spinning is presented as a method of obtaining tissue engineering scaffolds. The different forming modes were used and the optimum experimental conditions were found. It is shown that nonwoven polylactide scaffolds with required surface morphology can be obtained. These samples were studied in case of biodegradation in simulation body fluid. It was found that during scaffold dissolution the pH of the solution changes insignificantly (6.85) despite the exponential increase of the monomers of lactic acid. The calcium and phosphorus ion exchange between the scaffold and solution was observed in the surface and bulk of the material what makes possible to use scaffolds for regenerative medicine.

KW - Biodegradation

KW - In vitro

KW - Polylactic acide

KW - Polymer scaffold

KW - Simulation body fluid

KW - Solution blow spinning

UR - http://www.scopus.com/inward/record.url?scp=84891892921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891892921&partnerID=8YFLogxK

U2 - 10.4028/www.scientific.net/AMR.872.257

DO - 10.4028/www.scientific.net/AMR.872.257

M3 - Conference contribution

AN - SCOPUS:84891892921

SN - 9783037859667

T3 - Advanced Materials Research

SP - 257

EP - 262

BT - Nanomaterials for Structural, Functional and Biomedical Applications

T2 - Russian-German Forum on Nanotechnology

Y2 - 21 May 2013 through 24 May 2013

ER -