Nonwoven polylactide scaffolds obtained by solution blow spinning and the in vitro degradation dynamics

Sergei Tverdokhlebov, Ksenia Sergeevna Stankevich, Evgeny Bolbasov, Igor Albertovich Khlusov, Irina Kulagina, Konstantin Zaitsev

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

Abstract

The solution blow spinning is presented as a method of obtaining tissue engineering scaffolds. The different forming modes were used and the optimum experimental conditions were found. It is shown that nonwoven polylactide scaffolds with required surface morphology can be obtained. These samples were studied in case of biodegradation in simulation body fluid. It was found that during scaffold dissolution the pH of the solution changes insignificantly (6.85) despite the exponential increase of the monomers of lactic acid. The calcium and phosphorus ion exchange between the scaffold and solution was observed in the surface and bulk of the material what makes possible to use scaffolds for regenerative medicine.

Original languageEnglish
Title of host publicationNanomaterials for Structural, Functional and Biomedical Applications
Pages257-262
Number of pages6
DOIs
Publication statusPublished - 15 Jan 2014
EventRussian-German Forum on Nanotechnology - Tomsk, Russian Federation
Duration: 21 May 2013 → 24 May 2013

Publication series

NameAdvanced Materials Research
Volume872
ISSN (Print)1022-6680

Other

OtherRussian-German Forum on Nanotechnology
CountryRussian Federation
CityTomsk
Period21.5.13 → 24.5.13

Keywords

  • Biodegradation
  • In vitro
  • Polylactic acide
  • Polymer scaffold
  • Simulation body fluid
  • Solution blow spinning

ASJC Scopus subject areas

  • Engineering(all)

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