Nonpharmacological Correction of Hypersympatheticotonia in Patients with Chronic Coronary Insufficiency and Severe Left Ventricular Dysfunction

Sergey A. Afanasiev, Elena N. Pavliukova, Maria A. Kuzmichkina, Tatiana Yu Rebrova, Yana Anfinogenova, Konstantin S. Likhomanov, Rostislav S. Karpov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Control of sympathetic hyperactivity is pivotal for treatment of heart failure (HF) in patients with coronary artery disease (CAD). Our earlier studies demonstrated that the auricular pulsed electrical stimulation of the vagus nerve (VNS) beneficially affected condition of CAD patients with HF. The aim of our study was to evaluate changes in heart rate (HR) and the levels of heat shock proteins in peripheral blood lymphocytes in patients with CAD in the course of VNS. Methods: The study comprised 70 individuals aged 50-68 years with chronic coronary insufficiency, severe left ventricular dysfunction, and NYHA functional class (FC) III-IV HF. Main group included 63 patients who received VNS course (group 1). Control patients (n = 7) received sham therapy (group 2). Results: According to the results of 6-minute walk test and 24-hour ECG monitoring, administration of VNS improved clinical condition of 58 of 63 patients, decreased HF FC, and attenuated HR. Clinical condition in sham therapy group did not change. Immunoenzyme method demonstrated that hsp70 and hsp60 contents in peripheral blood lymphocyte lysate increased by 58% and 48% (P <0.05), respectively, in patients who initially had HR <80 bpm. The hsp70 level significantly increased and hsp60 level remained unchanged in patients with initial HR > 80 bpm. Conclusions: Correction of autonomous nervous status by VNS attenuated HR and improved functional state of the heart in CAD patients. Cardiotropic effect of VNS was the most pronounced in patients with preserved endogenous stress-limiting systems associated with hsp60 and/or hsp70.

Original languageEnglish
JournalAnnals of Noninvasive Electrocardiology
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Left Ventricular Dysfunction
Coronary Artery Disease
Heart Failure
Heart Rate
Group Psychotherapy
Lymphocytes
Vagus Nerve
Heat-Shock Proteins
Treatment Failure
Electric Stimulation
Electrocardiography

Keywords

  • Autonomous nervous system
  • Coronary artery disease
  • Heart failure
  • Heart rate, heat shock proteins
  • Vagus nerve stimulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Nonpharmacological Correction of Hypersympatheticotonia in Patients with Chronic Coronary Insufficiency and Severe Left Ventricular Dysfunction. / Afanasiev, Sergey A.; Pavliukova, Elena N.; Kuzmichkina, Maria A.; Rebrova, Tatiana Yu; Anfinogenova, Yana; Likhomanov, Konstantin S.; Karpov, Rostislav S.

In: Annals of Noninvasive Electrocardiology, 2016.

Research output: Contribution to journalArticle

Afanasiev, Sergey A. ; Pavliukova, Elena N. ; Kuzmichkina, Maria A. ; Rebrova, Tatiana Yu ; Anfinogenova, Yana ; Likhomanov, Konstantin S. ; Karpov, Rostislav S. / Nonpharmacological Correction of Hypersympatheticotonia in Patients with Chronic Coronary Insufficiency and Severe Left Ventricular Dysfunction. In: Annals of Noninvasive Electrocardiology. 2016.
@article{f7fb7e89b2724e77a7dfa84158ec45ac,
title = "Nonpharmacological Correction of Hypersympatheticotonia in Patients with Chronic Coronary Insufficiency and Severe Left Ventricular Dysfunction",
abstract = "Background: Control of sympathetic hyperactivity is pivotal for treatment of heart failure (HF) in patients with coronary artery disease (CAD). Our earlier studies demonstrated that the auricular pulsed electrical stimulation of the vagus nerve (VNS) beneficially affected condition of CAD patients with HF. The aim of our study was to evaluate changes in heart rate (HR) and the levels of heat shock proteins in peripheral blood lymphocytes in patients with CAD in the course of VNS. Methods: The study comprised 70 individuals aged 50-68 years with chronic coronary insufficiency, severe left ventricular dysfunction, and NYHA functional class (FC) III-IV HF. Main group included 63 patients who received VNS course (group 1). Control patients (n = 7) received sham therapy (group 2). Results: According to the results of 6-minute walk test and 24-hour ECG monitoring, administration of VNS improved clinical condition of 58 of 63 patients, decreased HF FC, and attenuated HR. Clinical condition in sham therapy group did not change. Immunoenzyme method demonstrated that hsp70 and hsp60 contents in peripheral blood lymphocyte lysate increased by 58{\%} and 48{\%} (P <0.05), respectively, in patients who initially had HR <80 bpm. The hsp70 level significantly increased and hsp60 level remained unchanged in patients with initial HR > 80 bpm. Conclusions: Correction of autonomous nervous status by VNS attenuated HR and improved functional state of the heart in CAD patients. Cardiotropic effect of VNS was the most pronounced in patients with preserved endogenous stress-limiting systems associated with hsp60 and/or hsp70.",
keywords = "Autonomous nervous system, Coronary artery disease, Heart failure, Heart rate, heat shock proteins, Vagus nerve stimulation",
author = "Afanasiev, {Sergey A.} and Pavliukova, {Elena N.} and Kuzmichkina, {Maria A.} and Rebrova, {Tatiana Yu} and Yana Anfinogenova and Likhomanov, {Konstantin S.} and Karpov, {Rostislav S.}",
year = "2016",
doi = "10.1111/anec.12349",
language = "English",
journal = "Annals of Noninvasive Electrocardiology",
issn = "1082-720X",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Nonpharmacological Correction of Hypersympatheticotonia in Patients with Chronic Coronary Insufficiency and Severe Left Ventricular Dysfunction

AU - Afanasiev, Sergey A.

AU - Pavliukova, Elena N.

AU - Kuzmichkina, Maria A.

AU - Rebrova, Tatiana Yu

AU - Anfinogenova, Yana

AU - Likhomanov, Konstantin S.

AU - Karpov, Rostislav S.

PY - 2016

Y1 - 2016

N2 - Background: Control of sympathetic hyperactivity is pivotal for treatment of heart failure (HF) in patients with coronary artery disease (CAD). Our earlier studies demonstrated that the auricular pulsed electrical stimulation of the vagus nerve (VNS) beneficially affected condition of CAD patients with HF. The aim of our study was to evaluate changes in heart rate (HR) and the levels of heat shock proteins in peripheral blood lymphocytes in patients with CAD in the course of VNS. Methods: The study comprised 70 individuals aged 50-68 years with chronic coronary insufficiency, severe left ventricular dysfunction, and NYHA functional class (FC) III-IV HF. Main group included 63 patients who received VNS course (group 1). Control patients (n = 7) received sham therapy (group 2). Results: According to the results of 6-minute walk test and 24-hour ECG monitoring, administration of VNS improved clinical condition of 58 of 63 patients, decreased HF FC, and attenuated HR. Clinical condition in sham therapy group did not change. Immunoenzyme method demonstrated that hsp70 and hsp60 contents in peripheral blood lymphocyte lysate increased by 58% and 48% (P <0.05), respectively, in patients who initially had HR <80 bpm. The hsp70 level significantly increased and hsp60 level remained unchanged in patients with initial HR > 80 bpm. Conclusions: Correction of autonomous nervous status by VNS attenuated HR and improved functional state of the heart in CAD patients. Cardiotropic effect of VNS was the most pronounced in patients with preserved endogenous stress-limiting systems associated with hsp60 and/or hsp70.

AB - Background: Control of sympathetic hyperactivity is pivotal for treatment of heart failure (HF) in patients with coronary artery disease (CAD). Our earlier studies demonstrated that the auricular pulsed electrical stimulation of the vagus nerve (VNS) beneficially affected condition of CAD patients with HF. The aim of our study was to evaluate changes in heart rate (HR) and the levels of heat shock proteins in peripheral blood lymphocytes in patients with CAD in the course of VNS. Methods: The study comprised 70 individuals aged 50-68 years with chronic coronary insufficiency, severe left ventricular dysfunction, and NYHA functional class (FC) III-IV HF. Main group included 63 patients who received VNS course (group 1). Control patients (n = 7) received sham therapy (group 2). Results: According to the results of 6-minute walk test and 24-hour ECG monitoring, administration of VNS improved clinical condition of 58 of 63 patients, decreased HF FC, and attenuated HR. Clinical condition in sham therapy group did not change. Immunoenzyme method demonstrated that hsp70 and hsp60 contents in peripheral blood lymphocyte lysate increased by 58% and 48% (P <0.05), respectively, in patients who initially had HR <80 bpm. The hsp70 level significantly increased and hsp60 level remained unchanged in patients with initial HR > 80 bpm. Conclusions: Correction of autonomous nervous status by VNS attenuated HR and improved functional state of the heart in CAD patients. Cardiotropic effect of VNS was the most pronounced in patients with preserved endogenous stress-limiting systems associated with hsp60 and/or hsp70.

KW - Autonomous nervous system

KW - Coronary artery disease

KW - Heart failure

KW - Heart rate, heat shock proteins

KW - Vagus nerve stimulation

UR - http://www.scopus.com/inward/record.url?scp=84960194689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960194689&partnerID=8YFLogxK

U2 - 10.1111/anec.12349

DO - 10.1111/anec.12349

M3 - Article

JO - Annals of Noninvasive Electrocardiology

JF - Annals of Noninvasive Electrocardiology

SN - 1082-720X

ER -