No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia

Abstract

Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia.

Original language	English
Pages (from-to)	334-337
Number of pages	4
Journal	Human Psychopharmacology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1002/hup.2226
Publication status	Published - May 2012

Keywords

ADORA2A
dyskinesia, tardive
mechanism

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Neurology
Pharmacology (medical)

Access to Document

10.1002/hup.2226

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No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia. / Ivanova, Svetlana A.; Al Hadithy, Asmar F Y; Brazovskaya, Natalia; Semke, Arkadiy; Wilffert, Bob; Fedorenko, Olga; Brouwers, Jacobus R B J; Loonen, Anton J M.

In: Human Psychopharmacology, Vol. 27, No. 3, 05.2012, p. 334-337.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia.",

keywords = "ADORA2A, dyskinesia, tardive, mechanism",

author = "Ivanova, {Svetlana A.} and {Al Hadithy}, {Asmar F Y} and Natalia Brazovskaya and Arkadiy Semke and Bob Wilffert and Olga Fedorenko and Brouwers, {Jacobus R B J} and Loonen, {Anton J M}",

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AU - Ivanova, Svetlana A.

AU - Al Hadithy, Asmar F Y

AU - Brazovskaya, Natalia

AU - Semke, Arkadiy

AU - Wilffert, Bob

AU - Fedorenko, Olga

AU - Brouwers, Jacobus R B J

AU - Loonen, Anton J M

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AB - Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia.

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