No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia

Svetlana A. Ivanova, Asmar F Y Al Hadithy, Natalia Brazovskaya, Arkadiy Semke, Bob Wilffert, Olga Fedorenko, Jacobus R B J Brouwers, Anton J M Loonen

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Abstract

Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia.

Original languageEnglish
Pages (from-to)334-337
Number of pages4
JournalHuman Psychopharmacology
Volume27
Issue number3
DOIs
Publication statusPublished - May 2012

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Keywords

  • ADORA2A
  • dyskinesia, tardive
  • mechanism

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Pharmacology (medical)

Cite this

Ivanova, S. A., Al Hadithy, A. F. Y., Brazovskaya, N., Semke, A., Wilffert, B., Fedorenko, O., ... Loonen, A. J. M. (2012). No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia. Human Psychopharmacology, 27(3), 334-337. https://doi.org/10.1002/hup.2226