Abstract
Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia.
| Original language | English |
|---|---|
| Pages (from-to) | 334-337 |
| Number of pages | 4 |
| Journal | Human Psychopharmacology |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2012 |
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Keywords
- ADORA2A
- dyskinesia, tardive
- mechanism
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Neurology
- Pharmacology (medical)
Cite this
No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia. / Ivanova, Svetlana A.; Al Hadithy, Asmar F Y; Brazovskaya, Natalia; Semke, Arkadiy; Wilffert, Bob; Fedorenko, Olga; Brouwers, Jacobus R B J; Loonen, Anton J M.
In: Human Psychopharmacology, Vol. 27, No. 3, 05.2012, p. 334-337.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia
AU - Ivanova, Svetlana A.
AU - Al Hadithy, Asmar F Y
AU - Brazovskaya, Natalia
AU - Semke, Arkadiy
AU - Wilffert, Bob
AU - Fedorenko, Olga
AU - Brouwers, Jacobus R B J
AU - Loonen, Anton J M
PY - 2012/5
Y1 - 2012/5
N2 - Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia.
AB - Background The adenosine A2A receptor forms a heteromeric complex with the striatal dopamine D2 receptor. We examined whether a specific polymorphism in adenosine A2A receptor (2592 C/Tins) is associated with tardive dyskinesia. Methods Tardive dyskinesia was assessed cross-sectionally in 146 Caucasian psychiatric inpatients from Siberia. Results Between-group comparisons of genotypic or allelic frequencies showed no statistically significant difference. Logistic regression analysis with the occurrence of tardive dyskinesia as dependent variable showed no significant association with age, duration of illness, gender, and genotype. Conclusion The interaction between the A2A and D2 receptors seems not involved in the development of tardive dyskinesia.
KW - ADORA2A
KW - dyskinesia, tardive
KW - mechanism
UR - http://www.scopus.com/inward/record.url?scp=84861152547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861152547&partnerID=8YFLogxK
U2 - 10.1002/hup.2226
DO - 10.1002/hup.2226
M3 - Article
C2 - 22585593
AN - SCOPUS:84861152547
VL - 27
SP - 334
EP - 337
JO - Human Psychopharmacology
JF - Human Psychopharmacology
SN - 0885-6222
IS - 3
ER -