NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension

Sergei N. Orlov, Svetlana V. Koltsova, Leonid V. Kapilevich, Svetlana V. Gusakova, Nickolai O. Dulin

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)


This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride cotransporters. These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid, respectively. Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume. However, the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds.

Original languageEnglish
Pages (from-to)186-196
Number of pages11
JournalGenes and Diseases
Issue number2
Publication statusPublished - 1 Jun 2015
Externally publishedYes


  • Hypertension
  • Intracellular chloride
  • Myogenic tone
  • Neuronal cell
  • NKCC cotransport
  • Smooth muscle

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Genetics(clinical)

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