NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension

Sergei N. Orlov, Svetlana V. Koltsova, Leonid V. Kapilevich, Svetlana V. Gusakova, Nickolai O. Dulin

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride cotransporters. These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid, respectively. Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume. However, the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds.

Original languageEnglish
Pages (from-to)186-196
Number of pages11
JournalGenes and Diseases
Volume2
Issue number2
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Fingerprint

Cations
Chlorides
Sodium-Potassium-Chloride Symporters
Hypertension
Sodium Potassium Chloride Symporter Inhibitors
Kidney
Fluids
Extracellular Fluid
Furosemide
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Protein Isoforms

Keywords

  • Hypertension
  • Intracellular chloride
  • Myogenic tone
  • Neuronal cell
  • NKCC cotransport
  • Smooth muscle

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Genetics(clinical)

Cite this

NKCC1 and NKCC2 : The pathogenetic role of cation-chloride cotransporters in hypertension. / Orlov, Sergei N.; Koltsova, Svetlana V.; Kapilevich, Leonid V.; Gusakova, Svetlana V.; Dulin, Nickolai O.

In: Genes and Diseases, Vol. 2, No. 2, 01.06.2015, p. 186-196.

Research output: Contribution to journalReview article

Orlov, Sergei N. ; Koltsova, Svetlana V. ; Kapilevich, Leonid V. ; Gusakova, Svetlana V. ; Dulin, Nickolai O. / NKCC1 and NKCC2 : The pathogenetic role of cation-chloride cotransporters in hypertension. In: Genes and Diseases. 2015 ; Vol. 2, No. 2. pp. 186-196.
@article{358ba02e73d841bb96e391e5be931146,
title = "NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension",
abstract = "This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride cotransporters. These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid, respectively. Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume. However, the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds.",
keywords = "Hypertension, Intracellular chloride, Myogenic tone, Neuronal cell, NKCC cotransport, Smooth muscle",
author = "Orlov, {Sergei N.} and Koltsova, {Svetlana V.} and Kapilevich, {Leonid V.} and Gusakova, {Svetlana V.} and Dulin, {Nickolai O.}",
year = "2015",
month = "6",
day = "1",
doi = "10.1016/j.gendis.2015.02.007",
language = "English",
volume = "2",
pages = "186--196",
journal = "Genes and Diseases",
issn = "2352-3042",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - NKCC1 and NKCC2

T2 - The pathogenetic role of cation-chloride cotransporters in hypertension

AU - Orlov, Sergei N.

AU - Koltsova, Svetlana V.

AU - Kapilevich, Leonid V.

AU - Gusakova, Svetlana V.

AU - Dulin, Nickolai O.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride cotransporters. These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid, respectively. Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume. However, the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds.

AB - This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride cotransporters. These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid, respectively. Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume. However, the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds.

KW - Hypertension

KW - Intracellular chloride

KW - Myogenic tone

KW - Neuronal cell

KW - NKCC cotransport

KW - Smooth muscle

UR - http://www.scopus.com/inward/record.url?scp=84978055825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978055825&partnerID=8YFLogxK

U2 - 10.1016/j.gendis.2015.02.007

DO - 10.1016/j.gendis.2015.02.007

M3 - Review article

AN - SCOPUS:84978055825

VL - 2

SP - 186

EP - 196

JO - Genes and Diseases

JF - Genes and Diseases

SN - 2352-3042

IS - 2

ER -