Nitraty v terapii stenokardii napriazheniia u bol'nykh s arterial'noi gipotenziei.

Translated title of the contribution: Nitrates in therapy of effort angina in hypotensive patients

E. M. Idrisova, N. V. Borovkova, E. A. Kladieva, V. I. Chernov, A. V. Demochko, A. A. Shishkina, E. V. Vorob'eva, R. S. Karpov

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Abstract

A randomized single blind cross-over trial with placebo lead-in has been conducted in 71 anginal patients with arterial hypotension (group 1) and 38 ischemic heart disease patients with normal arterial pressure (group 2) to compare efficacy of therapy with isosorbide dinitrate (ID), sustac-forte (SF), isosorbide dinitrate retard (IDR) and trinitrolong (TN). Paired bicycle exercises revealed that in group 1 patients ID was low effective in 49%, SF--in 61%, IDR was highly effective in 97% and TN--in 96%. In group 1 tolerance to antianginal effect of ID, SF and IDR shown by stress myocardial scintigraphy with Tl-199 developed earlier--in 2-4 weeks in 63-70% patients (versus 22-27% in group 2; p < 0.01). Recovery of ID, SF, IDR effect required prolongation of the drug withdrawal period to 8-16 days (versus 3-5 days in group 2; p < 0.05). TN therapy remained effective for 3 months. Resistance to ID, SF in group 1 was relative and depended on dosage form of nitrates.

Translated title of the contribution	Nitrates in therapy of effort angina in hypotensive patients
Original language	Russian
Pages (from-to)	54-58
Number of pages	5
Journal	Klinicheskaia meditsina
Volume	81
Issue number	11
Publication status	Published - 2003

ASJC Scopus subject areas

Medicine(all)

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@article{39ee4e9da92540c882a903f8620e4131,

title = "Nitraty v terapii stenokardii napriazheniia u bol'nykh s arterial'noi gipotenziei.",

abstract = "A randomized single blind cross-over trial with placebo lead-in has been conducted in 71 anginal patients with arterial hypotension (group 1) and 38 ischemic heart disease patients with normal arterial pressure (group 2) to compare efficacy of therapy with isosorbide dinitrate (ID), sustac-forte (SF), isosorbide dinitrate retard (IDR) and trinitrolong (TN). Paired bicycle exercises revealed that in group 1 patients ID was low effective in 49%, SF--in 61%, IDR was highly effective in 97% and TN--in 96%. In group 1 tolerance to antianginal effect of ID, SF and IDR shown by stress myocardial scintigraphy with Tl-199 developed earlier--in 2-4 weeks in 63-70% patients (versus 22-27% in group 2; p < 0.01). Recovery of ID, SF, IDR effect required prolongation of the drug withdrawal period to 8-16 days (versus 3-5 days in group 2; p < 0.05). TN therapy remained effective for 3 months. Resistance to ID, SF in group 1 was relative and depended on dosage form of nitrates.",

author = "Idrisova, {E. M.} and Borovkova, {N. V.} and Kladieva, {E. A.} and Chernov, {V. I.} and Demochko, {A. V.} and Shishkina, {A. A.} and Vorob'eva, {E. V.} and Karpov, {R. S.}",

year = "2003",

language = "Русский",

volume = "81",

pages = "54--58",

journal = "Klinicheskaya Meditsina",

issn = "0023-2149",

publisher = "Izdatel'stvo Meditsina",

number = "11",

}

TY - JOUR

T1 - Nitraty v terapii stenokardii napriazheniia u bol'nykh s arterial'noi gipotenziei.

AU - Idrisova, E. M.

AU - Borovkova, N. V.

AU - Kladieva, E. A.

AU - Chernov, V. I.

AU - Demochko, A. V.

AU - Shishkina, A. A.

AU - Vorob'eva, E. V.

AU - Karpov, R. S.

PY - 2003

Y1 - 2003

N2 - A randomized single blind cross-over trial with placebo lead-in has been conducted in 71 anginal patients with arterial hypotension (group 1) and 38 ischemic heart disease patients with normal arterial pressure (group 2) to compare efficacy of therapy with isosorbide dinitrate (ID), sustac-forte (SF), isosorbide dinitrate retard (IDR) and trinitrolong (TN). Paired bicycle exercises revealed that in group 1 patients ID was low effective in 49%, SF--in 61%, IDR was highly effective in 97% and TN--in 96%. In group 1 tolerance to antianginal effect of ID, SF and IDR shown by stress myocardial scintigraphy with Tl-199 developed earlier--in 2-4 weeks in 63-70% patients (versus 22-27% in group 2; p < 0.01). Recovery of ID, SF, IDR effect required prolongation of the drug withdrawal period to 8-16 days (versus 3-5 days in group 2; p < 0.05). TN therapy remained effective for 3 months. Resistance to ID, SF in group 1 was relative and depended on dosage form of nitrates.

AB - A randomized single blind cross-over trial with placebo lead-in has been conducted in 71 anginal patients with arterial hypotension (group 1) and 38 ischemic heart disease patients with normal arterial pressure (group 2) to compare efficacy of therapy with isosorbide dinitrate (ID), sustac-forte (SF), isosorbide dinitrate retard (IDR) and trinitrolong (TN). Paired bicycle exercises revealed that in group 1 patients ID was low effective in 49%, SF--in 61%, IDR was highly effective in 97% and TN--in 96%. In group 1 tolerance to antianginal effect of ID, SF and IDR shown by stress myocardial scintigraphy with Tl-199 developed earlier--in 2-4 weeks in 63-70% patients (versus 22-27% in group 2; p < 0.01). Recovery of ID, SF, IDR effect required prolongation of the drug withdrawal period to 8-16 days (versus 3-5 days in group 2; p < 0.05). TN therapy remained effective for 3 months. Resistance to ID, SF in group 1 was relative and depended on dosage form of nitrates.

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VL - 81

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