Abstract
NH-1,2,3-triazoles have been prepared via the copper(I)-catalyzed 1,3-dipolar cycloaddition between terminal alkynes and three N-protected organic azides, azidomethyl pivalate, azidomethyl morpholine-4-carboxylate, and azidomethyl N,N-diethylcarbarnate. These organic azides were easily prepared on 0.1-mol scale in one or two steps from inexpensive commercially available materials. The cleaving properties of N-substituents in the resulting 1,2,3-triazole products with aqueous sodium hydroxide vary from
Original language | English |
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Article number | Y06505ST |
Pages (from-to) | 2847-2850 |
Number of pages | 4 |
Journal | Synlett |
Issue number | 18 |
DOIs | |
Publication status | Published - 3 Nov 2005 |
Externally published | Yes |
Keywords
- Alkynes
- Azides
- Click chemistry
- Cycloaddition
- Heterocycles
- Protecting groups
- Triazoles
ASJC Scopus subject areas
- Organic Chemistry