NH-1,2,3-triazole inhibitors of the VIM-2 metallo-β-lactamase

Timo Weide, S. Adrian Saldanha, Dmitriy Minond, Timothy P. Spicer, Joseph R. Fotsing, Michael Spaargaren, Jean Marie Frère, Carine Bebrone, K. Barry Sharpless, Peter S. Hodder, Valery V. Fokin

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Metallo-β-lactamases (MBLs) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 β-lactamase is the most commonly encountered MBLs in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the β-lactam, imipenem, in Escherichia coli.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume1
Issue number4
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Bacterial Drug Resistance
Lactams
Triazoles
Imipenem
Escherichia coli
Anti-Bacterial Agents
Molecules

Keywords

  • bacterial resistance
  • Escherichia coli
  • Metallo-β-lactamases
  • NH-1,2,3-triazole-based inhibitors
  • VIM-2

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Biochemistry

Cite this

Weide, T., Saldanha, S. A., Minond, D., Spicer, T. P., Fotsing, J. R., Spaargaren, M., ... Fokin, V. V. (2010). NH-1,2,3-triazole inhibitors of the VIM-2 metallo-β-lactamase. ACS Medicinal Chemistry Letters, 1(4), 150-154. https://doi.org/10.1021/ml900022q

NH-1,2,3-triazole inhibitors of the VIM-2 metallo-β-lactamase. / Weide, Timo; Saldanha, S. Adrian; Minond, Dmitriy; Spicer, Timothy P.; Fotsing, Joseph R.; Spaargaren, Michael; Frère, Jean Marie; Bebrone, Carine; Sharpless, K. Barry; Hodder, Peter S.; Fokin, Valery V.

In: ACS Medicinal Chemistry Letters, Vol. 1, No. 4, 2010, p. 150-154.

Research output: Contribution to journalArticle

Weide, T, Saldanha, SA, Minond, D, Spicer, TP, Fotsing, JR, Spaargaren, M, Frère, JM, Bebrone, C, Sharpless, KB, Hodder, PS & Fokin, VV 2010, 'NH-1,2,3-triazole inhibitors of the VIM-2 metallo-β-lactamase', ACS Medicinal Chemistry Letters, vol. 1, no. 4, pp. 150-154. https://doi.org/10.1021/ml900022q
Weide T, Saldanha SA, Minond D, Spicer TP, Fotsing JR, Spaargaren M et al. NH-1,2,3-triazole inhibitors of the VIM-2 metallo-β-lactamase. ACS Medicinal Chemistry Letters. 2010;1(4):150-154. https://doi.org/10.1021/ml900022q
Weide, Timo ; Saldanha, S. Adrian ; Minond, Dmitriy ; Spicer, Timothy P. ; Fotsing, Joseph R. ; Spaargaren, Michael ; Frère, Jean Marie ; Bebrone, Carine ; Sharpless, K. Barry ; Hodder, Peter S. ; Fokin, Valery V. / NH-1,2,3-triazole inhibitors of the VIM-2 metallo-β-lactamase. In: ACS Medicinal Chemistry Letters. 2010 ; Vol. 1, No. 4. pp. 150-154.
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