NH-1,2,3-triazole inhibitors of the VIM-2 metallo-β-lactamase

Timo Weide, S. Adrian Saldanha, Dmitriy Minond, Timothy P. Spicer, Joseph R. Fotsing, Michael Spaargaren, Jean Marie Frère, Carine Bebrone, K. Barry Sharpless, Peter S. Hodder, Valery V. Fokin

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

Metallo-β-lactamases (MBLs) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 β-lactamase is the most commonly encountered MBLs in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the β-lactam, imipenem, in Escherichia coli.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume1
Issue number4
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • bacterial resistance
  • Escherichia coli
  • Metallo-β-lactamases
  • NH-1,2,3-triazole-based inhibitors
  • VIM-2

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Biochemistry

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