NH-1,2,3-triazole inhibitors of the VIM-2 metallo-β-lactamase

Timo Weide, S. Adrian Saldanha, Dmitriy Minond, Timothy P. Spicer, Joseph R. Fotsing, Michael Spaargaren, Jean Marie Frère, Carine Bebrone, K. Barry Sharpless, Peter S. Hodder, Valery V. Fokin

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


Metallo-β-lactamases (MBLs) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 β-lactamase is the most commonly encountered MBLs in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the β-lactam, imipenem, in Escherichia coli.

Original languageEnglish
Pages (from-to)150-154
Number of pages5
JournalACS Medicinal Chemistry Letters
Issue number4
Publication statusPublished - 2010
Externally publishedYes


  • bacterial resistance
  • Escherichia coli
  • Metallo-β-lactamases
  • NH-1,2,3-triazole-based inhibitors
  • VIM-2

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Biochemistry

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