New Synthetic Method and Antioxidant Activity of Betulin Diformate and Allobetulin Formate

Salah Arrous, Imene Boudebouz, I. Parunov, E. Plotnikov, O. Voronova

Research output: Contribution to journalArticle

Abstract

A simple and effective method for formylation of betulin using formic acid and 3a,6a-diphenylthioglycoluril is reported. The yield of betulin diformate was 87%. Allobetulin formate (95%) was prepared by reacting betulin diformate with trifluoroacetic acid. The structures of betulin diformate and allobetulin formate were confirmed by IR and NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.

Original languageEnglish
Pages (from-to)1094-1097
Number of pages4
JournalChemistry of Natural Compounds
Volume55
Issue number6
DOIs
Publication statusPublished - 1 Nov 2019

Fingerprint

betulin
formates
antioxidant activity
formic acid
infrared spectroscopy
methodology
nuclear magnetic resonance spectroscopy
acids

Keywords

  • allobetulin formate
  • betulin
  • betulin diformate
  • formic acid
  • formylation
  • organic catalyst
  • thioglycoluril

ASJC Scopus subject areas

  • Plant Science

Cite this

New Synthetic Method and Antioxidant Activity of Betulin Diformate and Allobetulin Formate. / Arrous, Salah; Boudebouz, Imene; Parunov, I.; Plotnikov, E.; Voronova, O.

In: Chemistry of Natural Compounds, Vol. 55, No. 6, 01.11.2019, p. 1094-1097.

Research output: Contribution to journalArticle

@article{37d8b080524c4fc4ae23f178bcbb450b,
title = "New Synthetic Method and Antioxidant Activity of Betulin Diformate and Allobetulin Formate",
abstract = "A simple and effective method for formylation of betulin using formic acid and 3a,6a-diphenylthioglycoluril is reported. The yield of betulin diformate was 87{\%}. Allobetulin formate (95{\%}) was prepared by reacting betulin diformate with trifluoroacetic acid. The structures of betulin diformate and allobetulin formate were confirmed by IR and NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.",
keywords = "allobetulin formate, betulin, betulin diformate, formic acid, formylation, organic catalyst, thioglycoluril",
author = "Salah Arrous and Imene Boudebouz and I. Parunov and E. Plotnikov and O. Voronova",
year = "2019",
month = "11",
day = "1",
doi = "10.1007/s10600-019-02902-5",
language = "English",
volume = "55",
pages = "1094--1097",
journal = "Chemistry of Natural Compounds",
issn = "0009-3130",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - New Synthetic Method and Antioxidant Activity of Betulin Diformate and Allobetulin Formate

AU - Arrous, Salah

AU - Boudebouz, Imene

AU - Parunov, I.

AU - Plotnikov, E.

AU - Voronova, O.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - A simple and effective method for formylation of betulin using formic acid and 3a,6a-diphenylthioglycoluril is reported. The yield of betulin diformate was 87%. Allobetulin formate (95%) was prepared by reacting betulin diformate with trifluoroacetic acid. The structures of betulin diformate and allobetulin formate were confirmed by IR and NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.

AB - A simple and effective method for formylation of betulin using formic acid and 3a,6a-diphenylthioglycoluril is reported. The yield of betulin diformate was 87%. Allobetulin formate (95%) was prepared by reacting betulin diformate with trifluoroacetic acid. The structures of betulin diformate and allobetulin formate were confirmed by IR and NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.

KW - allobetulin formate

KW - betulin

KW - betulin diformate

KW - formic acid

KW - formylation

KW - organic catalyst

KW - thioglycoluril

UR - http://www.scopus.com/inward/record.url?scp=85075131627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075131627&partnerID=8YFLogxK

U2 - 10.1007/s10600-019-02902-5

DO - 10.1007/s10600-019-02902-5

M3 - Article

AN - SCOPUS:85075131627

VL - 55

SP - 1094

EP - 1097

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

SN - 0009-3130

IS - 6

ER -