New Synthetic Method and Antioxidant Activity of Betulin Diformate and Allobetulin Formate

Abstract

A simple and effective method for formylation of betulin using formic acid and 3a,6a-diphenylthioglycoluril is reported. The yield of betulin diformate was 87%. Allobetulin formate (95%) was prepared by reacting betulin diformate with trifluoroacetic acid. The structures of betulin diformate and allobetulin formate were confirmed by IR and NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.

Original language	English
Pages (from-to)	1094-1097
Number of pages	4
Journal	Chemistry of Natural Compounds
Volume	55
Issue number	6
DOIs	https://doi.org/10.1007/s10600-019-02902-5
Publication status	Published - 1 Nov 2019

Keywords

allobetulin formate
betulin
betulin diformate
formic acid
formylation
organic catalyst
thioglycoluril

ASJC Scopus subject areas

Plant Science

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10.1007/s10600-019-02902-5

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title = "New Synthetic Method and Antioxidant Activity of Betulin Diformate and Allobetulin Formate",

abstract = "A simple and effective method for formylation of betulin using formic acid and 3a,6a-diphenylthioglycoluril is reported. The yield of betulin diformate was 87%. Allobetulin formate (95%) was prepared by reacting betulin diformate with trifluoroacetic acid. The structures of betulin diformate and allobetulin formate were confirmed by IR and NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.",

keywords = "allobetulin formate, betulin, betulin diformate, formic acid, formylation, organic catalyst, thioglycoluril",

author = "Salah Arrous and Imene Boudebouz and I. Parunov and E. Plotnikov and O. Voronova",

year = "2019",

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language = "English",

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T1 - New Synthetic Method and Antioxidant Activity of Betulin Diformate and Allobetulin Formate

AU - Arrous, Salah

AU - Boudebouz, Imene

AU - Parunov, I.

AU - Plotnikov, E.

AU - Voronova, O.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - A simple and effective method for formylation of betulin using formic acid and 3a,6a-diphenylthioglycoluril is reported. The yield of betulin diformate was 87%. Allobetulin formate (95%) was prepared by reacting betulin diformate with trifluoroacetic acid. The structures of betulin diformate and allobetulin formate were confirmed by IR and NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.

AB - A simple and effective method for formylation of betulin using formic acid and 3a,6a-diphenylthioglycoluril is reported. The yield of betulin diformate was 87%. Allobetulin formate (95%) was prepared by reacting betulin diformate with trifluoroacetic acid. The structures of betulin diformate and allobetulin formate were confirmed by IR and NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.

KW - allobetulin formate

KW - betulin

KW - betulin diformate

KW - formic acid

KW - formylation

KW - organic catalyst

KW - thioglycoluril

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