New surface-enhanced raman scattering platforms

Composite calcium carbonate microspheres coated with astralen and silver nanoparticles

Inna Y. Stetciura, Alexey V. Markin, Andrei N. Ponomarev, Alexander V. Yakimansky, Tatiana S. Demina, Cristian Grandfils, Dmitry V. Volodkin, Dmitry A. Gorin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Surface-enhanced Raman scattering (SERS) microspectroscopy is a very promising label-free, noncontact, and nondestructive method for real-time monitoring of extracellular matrix (ECM) development and cell integration in scaffolds for tissue engineering. Here, we prepare a new type of micrometer-sized SERS substrate, core-shell microparticles composed of solid carbonate core coated with silver nanoparticles and polyhedral multishell fullerene-like structure, astralen. Astralen has been assembled with polyallylamine hydrochloride (PAH) by the layer-by-layer manner followed by Ag nanoparticle formation by means of a silver mirror reaction, giving the final structure of composite particles CaCO3(PAH/astralen)x/Ag, where x = 1-3. The components of the microparticle carry multiple functionalities: (i) an easy identification by Raman imaging (photostable astralen) and (ii) SERS due to a rough surface of Ag nanoparticles. A combination of Ag and astralen nanoparticles provides an enhancement of astralen Raman signal by more than 1 order of magnitude. Raman signals of commonly used scaffold components such as polylactide and polyvinyl alcohol as well as ECM component (hyaluronic acid) are significantly enhanced. Thus, we demonstrate that new mechanically robust and easily detectable (by astralen signal or optically) core-shell microspheres based on biocompatible CaCO3 can be used as SERS platform. Particle design opens many future perspectives for fabrication of SERS platforms with multiple functions for biomedical applications, for example, for theranostic.

Original languageEnglish
Pages (from-to)4140-4147
Number of pages8
JournalLangmuir
Volume29
Issue number12
DOIs
Publication statusPublished - 26 Mar 2013
Externally publishedYes

Fingerprint

Calcium Carbonate
calcium carbonates
Calcium carbonate
Microspheres
Silver
Raman scattering
platforms
silver
Raman spectra
Nanoparticles
nanoparticles
composite materials
Composite materials
hydrochlorides
microparticles
Fullerenes
Polyvinyl Alcohol
Hyaluronic acid
tissue engineering
polyvinyl alcohol

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Stetciura, I. Y., Markin, A. V., Ponomarev, A. N., Yakimansky, A. V., Demina, T. S., Grandfils, C., ... Gorin, D. A. (2013). New surface-enhanced raman scattering platforms: Composite calcium carbonate microspheres coated with astralen and silver nanoparticles. Langmuir, 29(12), 4140-4147. https://doi.org/10.1021/la305117t

New surface-enhanced raman scattering platforms : Composite calcium carbonate microspheres coated with astralen and silver nanoparticles. / Stetciura, Inna Y.; Markin, Alexey V.; Ponomarev, Andrei N.; Yakimansky, Alexander V.; Demina, Tatiana S.; Grandfils, Cristian; Volodkin, Dmitry V.; Gorin, Dmitry A.

In: Langmuir, Vol. 29, No. 12, 26.03.2013, p. 4140-4147.

Research output: Contribution to journalArticle

Stetciura, IY, Markin, AV, Ponomarev, AN, Yakimansky, AV, Demina, TS, Grandfils, C, Volodkin, DV & Gorin, DA 2013, 'New surface-enhanced raman scattering platforms: Composite calcium carbonate microspheres coated with astralen and silver nanoparticles', Langmuir, vol. 29, no. 12, pp. 4140-4147. https://doi.org/10.1021/la305117t
Stetciura IY, Markin AV, Ponomarev AN, Yakimansky AV, Demina TS, Grandfils C et al. New surface-enhanced raman scattering platforms: Composite calcium carbonate microspheres coated with astralen and silver nanoparticles. Langmuir. 2013 Mar 26;29(12):4140-4147. https://doi.org/10.1021/la305117t
Stetciura, Inna Y. ; Markin, Alexey V. ; Ponomarev, Andrei N. ; Yakimansky, Alexander V. ; Demina, Tatiana S. ; Grandfils, Cristian ; Volodkin, Dmitry V. ; Gorin, Dmitry A. / New surface-enhanced raman scattering platforms : Composite calcium carbonate microspheres coated with astralen and silver nanoparticles. In: Langmuir. 2013 ; Vol. 29, No. 12. pp. 4140-4147.
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