New antirheumatic substance based on phenolic glycoside structure methyl (4-O-B-glucopyranosyloxy)-benzoic acid

Nemtsev Alexey, Smirnov Ivan, Murashko Tatyana, Ivanov Alexey, Bondarev Alex, Udut Vladimir

Research output: Contribution to journalArticle

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory multifactorial disorder affecting approximately 1% of population, with over 3000000 new cases annually. The principal pharmacological agents are nonsteroidal anti-inflammatory drugs (NSAID). Patients with rheumatoid arthritis are vulnerable to NSAID-associated gastrointestinal complications. Based on these findings we developed a new NSAID agent based on phenolic glycoside structure methyl (4-О-β-glucopyranosyloxy)-benzoic acid. In this study we evaluated the methyl (4-О-β-glucopyranosyloxy)-benzoic acid therapeutic effect in adjuvant-induced rat arthritis compared to etoricoxib effect. According to the results, methyl (4-О-β-glucopyranosyloxy)-benzoic acid activity was superior to etoricoxib, paw volume returned to the initial value 2 days early, than it did in etoricoxib group. Therefore, methyl (4-О-β-glucopyranosyloxy)-benzoic acid might contest to the modern antirheumatic drug etoricoxib.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalJurnal Teknologi
Volume78
Issue number6-8
DOIs
Publication statusPublished - 1 Jan 2016

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Glycosides
Benzoic acid
Rats

Keywords

  • Adjuvant arthritis
  • NSAID
  • Phenolic glycosides
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Engineering(all)

Cite this

New antirheumatic substance based on phenolic glycoside structure methyl (4-O-B-glucopyranosyloxy)-benzoic acid. / Alexey, Nemtsev; Ivan, Smirnov; Tatyana, Murashko; Alexey, Ivanov; Alex, Bondarev; Vladimir, Udut.

In: Jurnal Teknologi, Vol. 78, No. 6-8, 01.01.2016, p. 79-82.

Research output: Contribution to journalArticle

Alexey, Nemtsev ; Ivan, Smirnov ; Tatyana, Murashko ; Alexey, Ivanov ; Alex, Bondarev ; Vladimir, Udut. / New antirheumatic substance based on phenolic glycoside structure methyl (4-O-B-glucopyranosyloxy)-benzoic acid. In: Jurnal Teknologi. 2016 ; Vol. 78, No. 6-8. pp. 79-82.
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