Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders

L. A. Levchuk, N. M. Vyalova, G. G. Simutkin, N. A. Bokhan, S. A. Ivanova

Research output: Contribution to journalArticle

Abstract

We present a comprehensive clinical and biological study of 46 patients with depressive disorder (F32-F33: depressive episode and recurrent depressive disorder) during pharmacotherapy. Neurohumoral factors (cortisol, brain-derived neurotrophic factor, serotonin, DHEA and its sulfated form) were determined in serum by ELISA. The severity of the current depressive episode was evaluated using the 17-point Hamilton Depression Rating Scale (HDRS-17); the pharmacotherapy efficacy was evaluated using the scale of the Clinical Global Impression (CGI Scale). We showed that before prescription of pharmacotherapy peripheral blood neurohumoral markers that characterize the state of stress-realizing and stress-limiting systems of the body may be considered as biological predictors of the effective pharmacotherapy of a current depressive episode and used as additional paraclinical examination methods. At higher concentrations of cortisol and serotonin associated with a decrease in the content of neurosteroid dehydroepiandrosterone, the high efficiency of the pharmacotherapy of depressive episode is predicted.

Original languageEnglish
Pages (from-to)185-187
Number of pages3
JournalNeurochemical Journal
Volume11
Issue number2
DOIs
Publication statusPublished - 1 Apr 2017

Keywords

  • depressive disorder
  • neurohumoral system
  • pharmacotherapy

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cellular and Molecular Neuroscience

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