Neurohumoral indicators of efficacy radiofrequency cardiac denervation

A. V. Evtushenko, V. V. Evtushenko, Yu V. Saushkina, Yu B. Lishmanov, E. A. Pokushalov, D. S. Sergeevichev, A. M. Gusakova, T. E. Suslova, O. N. Dymbrylova, A. N. Bykov, V. I. Syryamkin, Yu V. Kistenev, Yana Jonovna Anfinogenova, K. A. Smyshlyaev, A. I. Lotkov, I. O. Kurlov

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In this study, we compared pre-and postoperative parameters of the cardiac sympathetic innervation. The aim of the study was to examine the approaches to evaluating the quality of radiofrequency (RF)-induced cardiac denervation by using non-invasive and laboratory methods. The study included 32 people with long-lasting persistent atrial fibrillation (AF). The patients were divided into 2 groups according to the objectives of the study: group 1 (main)-21 patients with mitral valve diseases, which simultaneously with radiofrequency ablation (RFA) AF carried out on the effects of the paraganglionic nervous plexuses by C. Pappone (2004) and N. Doll (2008) schemes. The second group (control) contained 11 patients with heart diseases in sinus rhythm (the RF denervation not been performed). All patients, who underwent surgical treatment, were received examination of cardiac sympathetic tone by using 123I-MIBG. All of them made blood analysis from ascending aorta and coronary sinus to determine the level of norepinephrine and its metabolites before and after cardiac denervation. Data of radionuclide examination are correlating with laboratory data.

Original languageEnglish
Title of host publicationNew Operational Technologies, NEWOT 2015: Proceedings of the 5th International Scientific Conference "New Operational Technologies"
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735413351
Publication statusPublished - 17 Nov 2015
Externally publishedYes
Event5th International Scientific Conference on New Operational Technologies, NEWOT 2015 - Tomsk, Russian Federation
Duration: 29 Sep 201530 Sep 2015


Conference5th International Scientific Conference on New Operational Technologies, NEWOT 2015
CountryRussian Federation

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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