Negishi cross-coupling reaction as a route to isocombretastatins

Yulia B. Malysheva, Svetlana Y. Buchvalova, Elena V. Svirshchevskaya, Valery V. Fokin, Alexey Y. Fedorov

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A series of isocombretastatins A has been synthesized by a new method based on the Negishi cross-coupling reaction in 19-84% yields. Five of the synthesized compounds exhibit high cytotoxic activity in nanomolar concentrations (IC50 = 1-100 n) towards Jurkat, K562, Colo357, and A549 cell lines.

Original languageEnglish
Article numberST-2013-B0387-L
Pages (from-to)1772-1776
Number of pages5
Issue number14
Publication statusPublished - 2013
Externally publishedYes


  • antitubulin agents
  • cytotoxicity
  • isocombretastatins
  • Negishi cross-coupling
  • turbo Grignard reagent

ASJC Scopus subject areas

  • Organic Chemistry

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