Negishi cross-coupling reaction as a route to isocombretastatins

Yulia B. Malysheva, Svetlana Y. Buchvalova, Elena V. Svirshchevskaya, Valery V. Fokin, Alexey Y. Fedorov

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A series of isocombretastatins A has been synthesized by a new method based on the Negishi cross-coupling reaction in 19-84% yields. Five of the synthesized compounds exhibit high cytotoxic activity in nanomolar concentrations (IC50 = 1-100 n) towards Jurkat, K562, Colo357, and A549 cell lines.

Original languageEnglish
Article numberST-2013-B0387-L
Pages (from-to)1772-1776
Number of pages5
JournalSynlett
Volume24
Issue number14
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Keywords

  • antitubulin agents
  • cytotoxicity
  • isocombretastatins
  • Negishi cross-coupling
  • turbo Grignard reagent

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Malysheva, Y. B., Buchvalova, S. Y., Svirshchevskaya, E. V., Fokin, V. V., & Fedorov, A. Y. (2013). Negishi cross-coupling reaction as a route to isocombretastatins. Synlett, 24(14), 1772-1776. [ST-2013-B0387-L]. https://doi.org/10.1055/s-0033-1339334

Negishi cross-coupling reaction as a route to isocombretastatins. / Malysheva, Yulia B.; Buchvalova, Svetlana Y.; Svirshchevskaya, Elena V.; Fokin, Valery V.; Fedorov, Alexey Y.

In: Synlett, Vol. 24, No. 14, ST-2013-B0387-L, 2013, p. 1772-1776.

Research output: Contribution to journalArticle

Malysheva, YB, Buchvalova, SY, Svirshchevskaya, EV, Fokin, VV & Fedorov, AY 2013, 'Negishi cross-coupling reaction as a route to isocombretastatins', Synlett, vol. 24, no. 14, ST-2013-B0387-L, pp. 1772-1776. https://doi.org/10.1055/s-0033-1339334
Malysheva YB, Buchvalova SY, Svirshchevskaya EV, Fokin VV, Fedorov AY. Negishi cross-coupling reaction as a route to isocombretastatins. Synlett. 2013;24(14):1772-1776. ST-2013-B0387-L. https://doi.org/10.1055/s-0033-1339334
Malysheva, Yulia B. ; Buchvalova, Svetlana Y. ; Svirshchevskaya, Elena V. ; Fokin, Valery V. ; Fedorov, Alexey Y. / Negishi cross-coupling reaction as a route to isocombretastatins. In: Synlett. 2013 ; Vol. 24, No. 14. pp. 1772-1776.
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