Abstract
A series of isocombretastatins A has been synthesized by a new method based on the Negishi cross-coupling reaction in 19-84% yields. Five of the synthesized compounds exhibit high cytotoxic activity in nanomolar concentrations (IC50 = 1-100 n) towards Jurkat, K562, Colo357, and A549 cell lines.
Original language | English |
---|---|
Article number | ST-2013-B0387-L |
Pages (from-to) | 1772-1776 |
Number of pages | 5 |
Journal | Synlett |
Volume | 24 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2013 |
Externally published | Yes |
Keywords
- antitubulin agents
- cytotoxicity
- isocombretastatins
- Negishi cross-coupling
- turbo Grignard reagent
ASJC Scopus subject areas
- Organic Chemistry