Negishi cross-coupling reaction as a route to isocombretastatins

Yulia B. Malysheva, Svetlana Y. Buchvalova, Elena V. Svirshchevskaya, Valery V. Fokin, Alexey Y. Fedorov

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7 Citations (Scopus)

Abstract

A series of isocombretastatins A has been synthesized by a new method based on the Negishi cross-coupling reaction in 19-84% yields. Five of the synthesized compounds exhibit high cytotoxic activity in nanomolar concentrations (IC50 = 1-100 n) towards Jurkat, K562, Colo357, and A549 cell lines.

Original languageEnglish
Article numberST-2013-B0387-L
Pages (from-to)1772-1776
Number of pages5
JournalSynlett
Volume24
Issue number14
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Keywords

  • antitubulin agents
  • cytotoxicity
  • isocombretastatins
  • Negishi cross-coupling
  • turbo Grignard reagent

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Malysheva, Y. B., Buchvalova, S. Y., Svirshchevskaya, E. V., Fokin, V. V., & Fedorov, A. Y. (2013). Negishi cross-coupling reaction as a route to isocombretastatins. Synlett, 24(14), 1772-1776. [ST-2013-B0387-L]. https://doi.org/10.1055/s-0033-1339334