Negishi cross-coupling reaction as a route to isocombretastatins

Yulia B. Malysheva, Svetlana Y. Buchvalova, Elena V. Svirshchevskaya, Valery V. Fokin, Alexey Y. Fedorov

Research output: Contribution to journal › Article

Abstract

A series of isocombretastatins A has been synthesized by a new method based on the Negishi cross-coupling reaction in 19-84% yields. Five of the synthesized compounds exhibit high cytotoxic activity in nanomolar concentrations (IC₅₀ = 1-100 n) towards Jurkat, K562, Colo357, and A549 cell lines.

Original language	English
Article number	ST-2013-B0387-L
Pages (from-to)	1772-1776
Number of pages	5
Journal	Synlett
Volume	24
Issue number	14
DOIs	https://doi.org/10.1055/s-0033-1339334
Publication status	Published - 2013
Externally published	Yes

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Keywords

antitubulin agents
cytotoxicity
isocombretastatins
Negishi cross-coupling
turbo Grignard reagent

ASJC Scopus subject areas

Organic Chemistry

Cite this

Malysheva, Y. B., Buchvalova, S. Y., Svirshchevskaya, E. V., Fokin, V. V., & Fedorov, A. Y. (2013). Negishi cross-coupling reaction as a route to isocombretastatins. Synlett, 24(14), 1772-1776. [ST-2013-B0387-L]. https://doi.org/10.1055/s-0033-1339334

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AU - Fokin, Valery V.

AU - Fedorov, Alexey Y.

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Access to Document

10.1055/s-0033-1339334