Negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated via non-opioid receptors

L. N. Maslov, Yu B. Lishmanov, E. I. Barzakh, T. V. Lasukova, K. K. Rice, P. R. Oeltgen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Ten-minute perfusion of intact isolated rat heart with Krebs - Henseleit solution containing δ-opioid receptor agonists (DPDPE, (-)-TAN-67) or δ-opioid receptor antagonists (naltrindole, TIPP[ψ], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the rates of myocardial contraction and relaxation. Intravenous injection of δ-agonists (DPDPE, (-)-TAN-67, deltorphin II) or δ-antagonists (naltrindole, TIPP[ψ], ICI 174,864) decreased HR in narcotized rats. Naloxone and naltrexone produced no effect on contractility and HR both in vivo and in vitro. Preliminary injection of naloxone and naltrexone did not prevent the negative chronotropic effect of ICI 174,864 in vitro. The negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated by unknown non-opioid receptors in the heart.

Original languageEnglish
Pages (from-to)420-423
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume141
Issue number4
DOIs
Publication statusPublished - 1 Apr 2006

Fingerprint

naltrindole
D-Penicillamine (2,5)-Enkephalin
Naltrexone
Narcotic Antagonists
Naloxone
Rats
Myocardial Contraction
Blood pressure
Opioid Receptors
Intravenous Injections
Heart Ventricles
Perfusion
Blood Pressure
Injections
tyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-phenylalanyl-phenylalanine
TAN 67
In Vitro Techniques

Keywords

  • δ-opioid receptor antagonists
  • Cardiac rhythm
  • Isolated perfused heart

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated via non-opioid receptors. / Maslov, L. N.; Lishmanov, Yu B.; Barzakh, E. I.; Lasukova, T. V.; Rice, K. K.; Oeltgen, P. R.

In: Bulletin of Experimental Biology and Medicine, Vol. 141, No. 4, 01.04.2006, p. 420-423.

Research output: Contribution to journalArticle

Maslov, L. N. ; Lishmanov, Yu B. ; Barzakh, E. I. ; Lasukova, T. V. ; Rice, K. K. ; Oeltgen, P. R. / Negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated via non-opioid receptors. In: Bulletin of Experimental Biology and Medicine. 2006 ; Vol. 141, No. 4. pp. 420-423.
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