Abstract
Ten-minute perfusion of intact isolated rat heart with Krebs - Henseleit solution containing δ-opioid receptor agonists (DPDPE, (-)-TAN-67) or δ-opioid receptor antagonists (naltrindole, TIPP[ψ], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the rates of myocardial contraction and relaxation. Intravenous injection of δ-agonists (DPDPE, (-)-TAN-67, deltorphin II) or δ-antagonists (naltrindole, TIPP[ψ], ICI 174,864) decreased HR in narcotized rats. Naloxone and naltrexone produced no effect on contractility and HR both in vivo and in vitro. Preliminary injection of naloxone and naltrexone did not prevent the negative chronotropic effect of ICI 174,864 in vitro. The negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated by unknown non-opioid receptors in the heart.
| Original language | English |
|---|---|
| Pages (from-to) | 420-423 |
| Number of pages | 4 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 141 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Apr 2006 |
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Keywords
- δ-opioid receptor antagonists
- Cardiac rhythm
- Isolated perfused heart
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated via non-opioid receptors. / Maslov, L. N.; Lishmanov, Yu B.; Barzakh, E. I.; Lasukova, T. V.; Rice, K. K.; Oeltgen, P. R.
In: Bulletin of Experimental Biology and Medicine, Vol. 141, No. 4, 01.04.2006, p. 420-423.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated via non-opioid receptors
AU - Maslov, L. N.
AU - Lishmanov, Yu B.
AU - Barzakh, E. I.
AU - Lasukova, T. V.
AU - Rice, K. K.
AU - Oeltgen, P. R.
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Ten-minute perfusion of intact isolated rat heart with Krebs - Henseleit solution containing δ-opioid receptor agonists (DPDPE, (-)-TAN-67) or δ-opioid receptor antagonists (naltrindole, TIPP[ψ], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the rates of myocardial contraction and relaxation. Intravenous injection of δ-agonists (DPDPE, (-)-TAN-67, deltorphin II) or δ-antagonists (naltrindole, TIPP[ψ], ICI 174,864) decreased HR in narcotized rats. Naloxone and naltrexone produced no effect on contractility and HR both in vivo and in vitro. Preliminary injection of naloxone and naltrexone did not prevent the negative chronotropic effect of ICI 174,864 in vitro. The negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated by unknown non-opioid receptors in the heart.
AB - Ten-minute perfusion of intact isolated rat heart with Krebs - Henseleit solution containing δ-opioid receptor agonists (DPDPE, (-)-TAN-67) or δ-opioid receptor antagonists (naltrindole, TIPP[ψ], ICI 174,864) at a final concentration of 0.1 mg/liter decreased HR, blood pressure in the left ventricle, and the rates of myocardial contraction and relaxation. Intravenous injection of δ-agonists (DPDPE, (-)-TAN-67, deltorphin II) or δ-antagonists (naltrindole, TIPP[ψ], ICI 174,864) decreased HR in narcotized rats. Naloxone and naltrexone produced no effect on contractility and HR both in vivo and in vitro. Preliminary injection of naloxone and naltrexone did not prevent the negative chronotropic effect of ICI 174,864 in vitro. The negative inotropic and chronotropic effects of δ-opioid receptor antagonists are mediated by unknown non-opioid receptors in the heart.
KW - δ-opioid receptor antagonists
KW - Cardiac rhythm
KW - Isolated perfused heart
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U2 - 10.1007/s10517-006-0188-y
DO - 10.1007/s10517-006-0188-y
M3 - Article
VL - 141
SP - 420
EP - 423
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 4
ER -