TY - JOUR
T1 - Nanoplasmonic Chitosan Nanofibers as Effective SERS Substrate for Detection of Small Molecules
AU - Severyukhina, Alexandra N.
AU - Parakhonskiy, Bogdan V.
AU - Prikhozhdenko, Ekaterina S.
AU - Gorin, Dmitry A.
AU - Sukhorukov, Gleb B.
AU - Möhwald, Helmuth
AU - Yashchenok, Alexey M.
PY - 2015/7/22
Y1 - 2015/7/22
N2 - The use of surface enhanced Raman spectroscopy (SERS) is limited by low reproducibility and uniformity of the response. Solving these problems can turn the laboratory use of SERS into real-world application. In this regard, soft SERS-active substrates can enable portable instrumentation and reduce costs in the fabrication of SERS-based sensors. Here, plasmonic free-standing films made of biocompatible chitosan nanofibers and gold nanoparticles are engineered by a simple protocol varying the concentration of chloroauric acid. The concentration and distribution of gold nanoparticles in films are controlled in a predictable way, and SERS spectra for the standard 2-naphthalenethiol with concentration less than 10-15 M are acquired in a reproducible way. The statistical analysis reveals a relatively high and locally uniform performance of SERS with an enhancement factor of 2 × 105 for 86% of the points on the imaged area of the SERS substrate. Potential SERS detection of small molecules, both Rhodamine 6G and d-Glucose, in the micromolar range is demonstrated.
AB - The use of surface enhanced Raman spectroscopy (SERS) is limited by low reproducibility and uniformity of the response. Solving these problems can turn the laboratory use of SERS into real-world application. In this regard, soft SERS-active substrates can enable portable instrumentation and reduce costs in the fabrication of SERS-based sensors. Here, plasmonic free-standing films made of biocompatible chitosan nanofibers and gold nanoparticles are engineered by a simple protocol varying the concentration of chloroauric acid. The concentration and distribution of gold nanoparticles in films are controlled in a predictable way, and SERS spectra for the standard 2-naphthalenethiol with concentration less than 10-15 M are acquired in a reproducible way. The statistical analysis reveals a relatively high and locally uniform performance of SERS with an enhancement factor of 2 × 105 for 86% of the points on the imaged area of the SERS substrate. Potential SERS detection of small molecules, both Rhodamine 6G and d-Glucose, in the micromolar range is demonstrated.
KW - chitosan nanofibers
KW - d -Glucose
KW - gold nanoparticles
KW - Rhodamine 6G
KW - SERS
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U2 - 10.1021/acsami.5b03696
DO - 10.1021/acsami.5b03696
M3 - Article
C2 - 26126080
AN - SCOPUS:84937707252
VL - 7
SP - 15466
EP - 15473
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
IS - 28
ER -