Nanoparticles based on star-shaped carboxy-terminated polylactide and chitosan for controlled release applications

Antonio Di Martino, Pavel Kucharczyk, Vladimir Sedlarik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work chitosan based nanoparticles were prepared and modified by a star-shaped carboxy-terminated polylactide (S-PLA) in order to reduce the doxorubicin burst effect in physiological solution. S-PLA was prepared by polycondensation reaction using pentetic acid as a core molecule and methansulfonic acid as catalyst and linked to chitosan backbone through coupling reaction. Afterwards, chitosan-(S-PLA) modified nanoparticles loaded with doxorubicin were prepared by polyelectrolytes complexation method using dextran sulphate sodium salt as polyanion. Results show nanoparticles with diameter in the range 100-200 nm, spherical shape and ζ-potential between 27-35 mV. The presence of (S-PLA) side chain does not influence the encapsulation efficiency of the drug but strongly reduce the initial burst effect compared with unmodified chitosan.

Original languageEnglish
Title of host publicationNANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings
PublisherTANGER Ltd.
Pages394-398
Number of pages5
ISBN (Electronic)9788087294635
Publication statusPublished - 1 Jan 2015
Externally publishedYes
Event7th International Conference on Nanomaterials - Research and Application, NANOCON 2015 - Brno, Czech Republic
Duration: 14 Oct 201516 Oct 2015

Publication series

NameNANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings

Conference

Conference7th International Conference on Nanomaterials - Research and Application, NANOCON 2015
CountryCzech Republic
CityBrno
Period14.10.1516.10.15

Fingerprint

Chitosan
Nanoparticles
Stars
Doxorubicin
Pentetic Acid
Dextran Sulfate
Sodium sulfate
Dextran
Acids
Polycondensation
Polyelectrolytes
Complexation
Encapsulation
Salts
Catalysts
Molecules
poly(lactide)
Pharmaceutical Preparations

Keywords

  • Burst effect
  • Chitosan
  • Doxorubicin
  • Drug delivery
  • Polylactide

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Electrical and Electronic Engineering
  • Biotechnology

Cite this

Di Martino, A., Kucharczyk, P., & Sedlarik, V. (2015). Nanoparticles based on star-shaped carboxy-terminated polylactide and chitosan for controlled release applications. In NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings (pp. 394-398). (NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings). TANGER Ltd..

Nanoparticles based on star-shaped carboxy-terminated polylactide and chitosan for controlled release applications. / Di Martino, Antonio; Kucharczyk, Pavel; Sedlarik, Vladimir.

NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings. TANGER Ltd., 2015. p. 394-398 (NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Di Martino, A, Kucharczyk, P & Sedlarik, V 2015, Nanoparticles based on star-shaped carboxy-terminated polylactide and chitosan for controlled release applications. in NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings. NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings, TANGER Ltd., pp. 394-398, 7th International Conference on Nanomaterials - Research and Application, NANOCON 2015, Brno, Czech Republic, 14.10.15.
Di Martino A, Kucharczyk P, Sedlarik V. Nanoparticles based on star-shaped carboxy-terminated polylactide and chitosan for controlled release applications. In NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings. TANGER Ltd. 2015. p. 394-398. (NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings).
Di Martino, Antonio ; Kucharczyk, Pavel ; Sedlarik, Vladimir. / Nanoparticles based on star-shaped carboxy-terminated polylactide and chitosan for controlled release applications. NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings. TANGER Ltd., 2015. pp. 394-398 (NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings).
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