Nanoparticles based on star-shaped carboxy-terminated polylactide and chitosan for controlled release applications

Antonio Di Martino, Pavel Kucharczyk, Vladimir Sedlarik

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work chitosan based nanoparticles were prepared and modified by a star-shaped carboxy-terminated polylactide (S-PLA) in order to reduce the doxorubicin burst effect in physiological solution. S-PLA was prepared by polycondensation reaction using pentetic acid as a core molecule and methansulfonic acid as catalyst and linked to chitosan backbone through coupling reaction. Afterwards, chitosan-(S-PLA) modified nanoparticles loaded with doxorubicin were prepared by polyelectrolytes complexation method using dextran sulphate sodium salt as polyanion. Results show nanoparticles with diameter in the range 100-200 nm, spherical shape and ζ-potential between 27-35 mV. The presence of (S-PLA) side chain does not influence the encapsulation efficiency of the drug but strongly reduce the initial burst effect compared with unmodified chitosan.

Original languageEnglish
Title of host publicationNANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings
PublisherTANGER Ltd.
Pages394-398
Number of pages5
ISBN (Electronic)9788087294635
Publication statusPublished - 1 Jan 2015
Externally publishedYes
Event7th International Conference on Nanomaterials - Research and Application, NANOCON 2015 - Brno, Czech Republic
Duration: 14 Oct 201516 Oct 2015

Publication series

NameNANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings

Conference

Conference7th International Conference on Nanomaterials - Research and Application, NANOCON 2015
CountryCzech Republic
CityBrno
Period14.10.1516.10.15

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Keywords

  • Burst effect
  • Chitosan
  • Doxorubicin
  • Drug delivery
  • Polylactide

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Electrical and Electronic Engineering
  • Biotechnology

Cite this

Di Martino, A., Kucharczyk, P., & Sedlarik, V. (2015). Nanoparticles based on star-shaped carboxy-terminated polylactide and chitosan for controlled release applications. In NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings (pp. 394-398). (NANOCON 2015 - 7th International Conference on Nanomaterials - Research and Application, Conference Proceedings). TANGER Ltd..