Titanium scaffolds can be prepared by wet chemical means (CSA) with a novel primary surface and a characteristic structure in the form of nano-spheroids. This surface displays novel physicochemical and biological functions in the form of ultra-hydrophilicity and osteophilicity. A novel secondary surface can be prepared on the primary one by immobilizing rhBMP-2 comprising the surface structure. Physicochemically these latter surfaces show a controlled release of rhBMP-2 with a half-life in the range of 20-60 days and a novel biochemical function in form of osteoinductivity. Thus ultra-hydrophilic titanium surfaces appear to be a novel scaffold in their own right for osteoconductive and the rhBMP-2 coated biocoated titanium surfaces for osteoinductive bone growth. Especially the latter surface provides an efficient scaffold for in vivo bone-tissue engineering. Both the osteophilic and the osteoinductive properties of the novel surfaces can be shown in an in vivo model in dog tibia by significant increases in the induced bone density (BD) at a distance of ca. 1 mm from the adjacent implant.
|Number of pages||12|
|Publication status||Published - 2005|
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