Abstract
Chronic treatment with opioid receptor ligands: nonselective peptide opioid receptor agonist dalargin (intraperitoneally in a dose of 1 mg/kg), selective nonpeptide κ-receptor agonist GR 89696 (subcutaneously in a dose of 0.03 mg/kg), nonselectrive nonpeptide antagonist quadazocine (subcutaneously in a dose of 3 mg/kg) or naltrexone (subcutaneously in a dose of 10 mg/kg) for 20 day had no effect of the incidence of ischemic ventricular arrhythmias and the size of necrotic zone after coronary occlusion and reperfusion in rats in vivo.
Original language | English |
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Pages (from-to) | 696-699 |
Number of pages | 4 |
Journal | Bulletin of Experimental Biology and Medicine |
Volume | 145 |
Issue number | 6 |
DOIs | |
Publication status | Published - 19 Nov 2008 |
Keywords
- Chronic treatment with opioid receptor agonists
- Ischemia
- Myocardium
- Reperfusion
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)