Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists

Yu B. Lishmanov, D. L. Stakheev, A. V. Krylatov, N. V. Naryzhnaya, L. N. Maslov, M. V. Ovchinnikov, F. Kolar

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Abstract

Chronic treatment with opioid receptor ligands: nonselective peptide opioid receptor agonist dalargin (intraperitoneally in a dose of 1 mg/kg), selective nonpeptide κ-receptor agonist GR 89696 (subcutaneously in a dose of 0.03 mg/kg), nonselectrive nonpeptide antagonist quadazocine (subcutaneously in a dose of 3 mg/kg) or naltrexone (subcutaneously in a dose of 10 mg/kg) for 20 day had no effect of the incidence of ischemic ventricular arrhythmias and the size of necrotic zone after coronary occlusion and reperfusion in rats in vivo.

Original language	English
Pages (from-to)	696-699
Number of pages	4
Journal	Bulletin of Experimental Biology and Medicine
Volume	145
Issue number	6
DOIs	https://doi.org/10.1007/s10517-008-0172-9
Publication status	Published - 19 Nov 2008

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Keywords

Chronic treatment with opioid receptor agonists
Ischemia
Myocardium
Reperfusion

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lishmanov, Y. B., Stakheev, D. L., Krylatov, A. V., Naryzhnaya, N. V., Maslov, L. N., Ovchinnikov, M. V., & Kolar, F. (2008). Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists. Bulletin of Experimental Biology and Medicine, 145(6), 696-699. https://doi.org/10.1007/s10517-008-0172-9

Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists. / Lishmanov, Yu B.; Stakheev, D. L.; Krylatov, A. V.; Naryzhnaya, N. V.; Maslov, L. N.; Ovchinnikov, M. V.; Kolar, F.

In: Bulletin of Experimental Biology and Medicine, Vol. 145, No. 6, 19.11.2008, p. 696-699.

Research output: Contribution to journal › Article

Lishmanov, YB, Stakheev, DL, Krylatov, AV, Naryzhnaya, NV, Maslov, LN, Ovchinnikov, MV & Kolar, F 2008, 'Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists', Bulletin of Experimental Biology and Medicine, vol. 145, no. 6, pp. 696-699. https://doi.org/10.1007/s10517-008-0172-9

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Access to Document

10.1007/s10517-008-0172-9