Mutagen properties of water-soluble polysaccharides from Acorus calamus

A. M. Gur'ev, M. V. Belousov, R. R. Akhmedzhanov, M. S. Yusubov, O. L. Voronova, G. V. Karpova, A. A. Churin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Mutagenic properties of water soluble polysaccharides (WSPS) extracted from Acorus calamus L. have been studied. Neither a single intravenous injection nor a course intraperitoneal introduction of WSPS in a dose of 1/2 LD50 to mice of the CBA/CaLac line increases the level of cytogenetic disorders in the bone marrow cells. The investigation of WSPS by means of the somatic mosaicism test showed that the given dose of WSPS does not increase the rate of mutant spots on Drosophila wings.

Original languageEnglish
Pages (from-to)43-45
Number of pages3
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume73
Issue number8
Publication statusPublished - 2010

Keywords

  • Acorus calamus
  • Genotoxicity
  • Mutagenicity
  • Water soluble polysaccharides

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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