Multifunctional polyelectrolyte microcapsules as a contrast agent for photoacoustic imaging in blood

Alexey M. Yashchenok, Jithin Jose, Philippe Trochet, Gleb B. Sukhorukov, Dmitry A. Gorin

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    The polyelectrolyte microcapsules that can be accurate either visualized in biological media or in tissue would enhance their further in vivo application both as a carrier of active payloads and as a specific sensor. The immobilization of active species, for instance fluorescent dyes, quantum dots, metal nanoparticles, in polymeric shell enables visualization of capsules by optical imaging techniques in aqueous solution. However, for visualization of capsules in complex media an instrument with high contrast modality requires. Herein, we show for the first time photoacoustic imaging (PAI) of multifunctional microcapsules in water and in blood. The microcapsules exhibit greater photoacoustic intensity compare to microparticles with the same composition of polymeric shell presumably their higher thermal expansion. Photoacoustic intensity form microcapsules dispersed in blood displays an enhancement (2-fold) of signal compare to blood. Photoacoustic imaging of microcapsules might contribute to non-invasive carrier visualization and further their in vivo distribution. (Figure presented.).

    Original languageEnglish
    Pages (from-to)792-799
    Number of pages8
    JournalJournal of Biophotonics
    Volume9
    Issue number8
    DOIs
    Publication statusPublished - 1 Aug 2016

    Fingerprint

    Photoacoustic effect
    Polyelectrolytes
    Contrast Media
    blood
    Capsules
    Blood
    capsules
    Imaging techniques
    Visualization
    microparticles
    immobilization
    payloads
    imaging techniques
    Metal nanoparticles
    thermal expansion
    dyes
    quantum dots
    Semiconductor quantum dots
    aqueous solutions
    Thermal expansion

    Keywords

    • blood
    • gold nanoparticles
    • photoacoustic imaging
    • polyelectrolyte microcapsules

    ASJC Scopus subject areas

    • Materials Science(all)
    • Engineering(all)
    • Physics and Astronomy(all)
    • Chemistry(all)
    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Multifunctional polyelectrolyte microcapsules as a contrast agent for photoacoustic imaging in blood. / Yashchenok, Alexey M.; Jose, Jithin; Trochet, Philippe; Sukhorukov, Gleb B.; Gorin, Dmitry A.

    In: Journal of Biophotonics, Vol. 9, No. 8, 01.08.2016, p. 792-799.

    Research output: Contribution to journalArticle

    Yashchenok, Alexey M. ; Jose, Jithin ; Trochet, Philippe ; Sukhorukov, Gleb B. ; Gorin, Dmitry A. / Multifunctional polyelectrolyte microcapsules as a contrast agent for photoacoustic imaging in blood. In: Journal of Biophotonics. 2016 ; Vol. 9, No. 8. pp. 792-799.
    @article{3a78342049d14806a1a70c7369fd88a5,
    title = "Multifunctional polyelectrolyte microcapsules as a contrast agent for photoacoustic imaging in blood",
    abstract = "The polyelectrolyte microcapsules that can be accurate either visualized in biological media or in tissue would enhance their further in vivo application both as a carrier of active payloads and as a specific sensor. The immobilization of active species, for instance fluorescent dyes, quantum dots, metal nanoparticles, in polymeric shell enables visualization of capsules by optical imaging techniques in aqueous solution. However, for visualization of capsules in complex media an instrument with high contrast modality requires. Herein, we show for the first time photoacoustic imaging (PAI) of multifunctional microcapsules in water and in blood. The microcapsules exhibit greater photoacoustic intensity compare to microparticles with the same composition of polymeric shell presumably their higher thermal expansion. Photoacoustic intensity form microcapsules dispersed in blood displays an enhancement (2-fold) of signal compare to blood. Photoacoustic imaging of microcapsules might contribute to non-invasive carrier visualization and further their in vivo distribution. (Figure presented.).",
    keywords = "blood, gold nanoparticles, photoacoustic imaging, polyelectrolyte microcapsules",
    author = "Yashchenok, {Alexey M.} and Jithin Jose and Philippe Trochet and Sukhorukov, {Gleb B.} and Gorin, {Dmitry A.}",
    year = "2016",
    month = "8",
    day = "1",
    doi = "10.1002/jbio.201500293",
    language = "English",
    volume = "9",
    pages = "792--799",
    journal = "Journal of Biophotonics",
    issn = "1864-063X",
    publisher = "Wiley-VCH Verlag",
    number = "8",

    }

    TY - JOUR

    T1 - Multifunctional polyelectrolyte microcapsules as a contrast agent for photoacoustic imaging in blood

    AU - Yashchenok, Alexey M.

    AU - Jose, Jithin

    AU - Trochet, Philippe

    AU - Sukhorukov, Gleb B.

    AU - Gorin, Dmitry A.

    PY - 2016/8/1

    Y1 - 2016/8/1

    N2 - The polyelectrolyte microcapsules that can be accurate either visualized in biological media or in tissue would enhance their further in vivo application both as a carrier of active payloads and as a specific sensor. The immobilization of active species, for instance fluorescent dyes, quantum dots, metal nanoparticles, in polymeric shell enables visualization of capsules by optical imaging techniques in aqueous solution. However, for visualization of capsules in complex media an instrument with high contrast modality requires. Herein, we show for the first time photoacoustic imaging (PAI) of multifunctional microcapsules in water and in blood. The microcapsules exhibit greater photoacoustic intensity compare to microparticles with the same composition of polymeric shell presumably their higher thermal expansion. Photoacoustic intensity form microcapsules dispersed in blood displays an enhancement (2-fold) of signal compare to blood. Photoacoustic imaging of microcapsules might contribute to non-invasive carrier visualization and further their in vivo distribution. (Figure presented.).

    AB - The polyelectrolyte microcapsules that can be accurate either visualized in biological media or in tissue would enhance their further in vivo application both as a carrier of active payloads and as a specific sensor. The immobilization of active species, for instance fluorescent dyes, quantum dots, metal nanoparticles, in polymeric shell enables visualization of capsules by optical imaging techniques in aqueous solution. However, for visualization of capsules in complex media an instrument with high contrast modality requires. Herein, we show for the first time photoacoustic imaging (PAI) of multifunctional microcapsules in water and in blood. The microcapsules exhibit greater photoacoustic intensity compare to microparticles with the same composition of polymeric shell presumably their higher thermal expansion. Photoacoustic intensity form microcapsules dispersed in blood displays an enhancement (2-fold) of signal compare to blood. Photoacoustic imaging of microcapsules might contribute to non-invasive carrier visualization and further their in vivo distribution. (Figure presented.).

    KW - blood

    KW - gold nanoparticles

    KW - photoacoustic imaging

    KW - polyelectrolyte microcapsules

    UR - http://www.scopus.com/inward/record.url?scp=84982976071&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84982976071&partnerID=8YFLogxK

    U2 - 10.1002/jbio.201500293

    DO - 10.1002/jbio.201500293

    M3 - Article

    VL - 9

    SP - 792

    EP - 799

    JO - Journal of Biophotonics

    JF - Journal of Biophotonics

    SN - 1864-063X

    IS - 8

    ER -